4,4'Thiobis-(2-methyl-6-tert.-butylanisol) | 54519-54-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4,4'Thiobis-(2-methyl-6-tert.-butylanisol)
• 英文别名: Bis(4-methoxy-3-methyl-5-t-butylphenyl)sulfide；1-tert-butyl-5-(3-tert-butyl-4-methoxy-5-methylphenyl)sulfanyl-2-methoxy-3-methylbenzene
• CAS: 54519-54-9
• 化学式: C₂₄H₃₄O₂S
• 分子量: 386.599
• InChiKey: MAYNYNQYXGDONA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,4'-硫联二(6-叔丁基-2-甲基苯酚) 、 硫酸二甲酯 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 4,4'Thiobis-(2-methyl-6-tert.-butylanisol)
  参考文献：
  名称：

  Jirackova,L.; Pospisil,J., Collection of Czechoslovak Chemical Communications, 1974, vol. 39, p. 2792 - 2795

  摘要：

  DOI：

文献信息

• NOVEL PROCESS AND INTERMEDIATES
  申请人：Gore Vinayak G.

  公开号：US20090177001A1

  公开（公告）日：2009-07-09

  The present invention relates to a process for the preparation of steroidal 17β-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17β-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.

  本发明涉及一种制备类固醇17β-羧基硫酸酯的过程。更具体地说，本发明涉及使用可溶性混合氟化物通过置换化合物II中适当的离去基X引入氟，从而选择性地和可控地氟化制备类固醇17β-羧基硫酸酯（如丙酸氟替卡松I）的方便和高效合成。本发明还涉及中间体II及其制备。
• Process for the preparation of S-fluoromethyl-6,9-difluoro-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1,4-diene-17-carbothioate and intermediates
  申请人：Generics (UK) Limited

  公开号：EP2402360A1

  公开（公告）日：2012-01-04

  The present invention relates to a process for the preparation of steroidal 17β-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17β-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.

  本发明涉及一种制备甾体 17β-羧基硫代酸酯的工艺。 更具体地说，本发明涉及一种方便有效地合成甾体 17β-羧基硫代酸酯（如氟替卡松丙酸酯 I）的方法，该方法使用可溶性混合氟化物，通过置换化合物 II 中的适当离去基团 X 来引入氟，从而实现选择性和受控氟化。 本发明还涉及中间体 II 及其制备。
• PROCESS FOR THE PREPARATION OF S-FLUOROMETHYL-6 ,9 -DIFLUORO-11 -HYDROXY-16 -METHYL-17 -PROPIONYLOXY-3-OXO-ANDROSTA-1,4-DIENE-17 -CARBOTHIOATE AND INTERMEDIATES
  申请人：Generics (UK) Limited

  公开号：EP2044099A2

  公开（公告）日：2009-04-08
• PROCESS FOR THE PREPARATION OF S-FLUOROMETHYL-6,9-DIFLUORO-11-HYDROXY-16-METHYL-17-PROPIONYLOXY-3-OXO-ANDROSTA-1,4-DIENE-17-CARBOTHIOATE AND INTERMEDIATES
  申请人：Generics [UK] Limited

  公开号：EP2402361B1

  公开（公告）日：2020-04-15
• Process for the Preparation of Fluticasone Propionate
  申请人：Generics [UK] Limited

  公开号：US20130172587A1

  公开（公告）日：2013-07-04

  The present invention relates to a process for the preparation of steroidal 17β-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17β-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.