(3-hydroxy-5-methoxyphenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone | 1260505-24-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: (3-hydroxy-5-methoxyphenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone
• 英文别名: (3-Hydroxy-5-methoxy-phenyl)-[2-(4-methoxyphenyl)-5-methyl-benzofuran-3-yl]methanone；(3-hydroxy-5-methoxyphenyl)-[2-(4-methoxyphenyl)-5-methyl-1-benzofuran-3-yl]methanone
• CAS: 1260505-24-5
• 化学式: C₂₄H₂₀O₅
• 分子量: 388.42
• InChiKey: KYAQIVVDVOHMEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  68.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-碘-4-甲基苯酚 在 吡啶 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 四氯化锡 、 potassium carbonate 、 三乙胺 、 potassium hydroxide 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 (3-hydroxy-5-methoxyphenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone
  参考文献：
  名称：

  Synthesis and antimicrobial evaluation of new benzofuran derivatives

  摘要：

  Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus sub fills, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC80 = 0.39-3.12 mu g/mL), which were better than the control drugs. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.04.053

文献信息

• Synthesis and antimicrobial evaluation of new benzofuran derivatives
  作者：Xizhen Jiang、Wenlu Liu、Wei Zhang、Faqin Jiang、Zhe Gao、Hao Zhuang、Lei Fu

  DOI：10.1016/j.ejmech.2011.04.053

  日期：2011.8

  Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus sub fills, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC80 = 0.39-3.12 mu g/mL), which were better than the control drugs. (C) 2011 Elsevier Masson SAS. All rights reserved.