(S)-2-(4-chloro-phenyl)-propionic acid amide | 190725-14-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-(4-chloro-phenyl)-propionic acid amide
• 英文别名: (S)-2-(4-Chlor-phenyl)-propionsaeure-amid；(2S)-2-(4-chlorophenyl)propanamide
• CAS: 190725-14-5
• 化学式: C₉H₁₀ClNO
• 分子量: 183.637
• InChiKey: RMSRXEUMWACGGJ-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (S)-2-(4-chlorophenyl)propanoic acid 在 氯化亚砜 作用下， 生成 (S)-2-(4-chloro-phenyl)-propionic acid amide
  参考文献：
  名称：

  A separation method for DNA computing based on concentration control

  摘要：

  A separation method for DNA computing based on concentration control is presented. The concentration control method was earlier developed and has enabled us to use DNA concentrations as input data and as filters to extract target DNA. We have also applied the method to the shortest path problems, and have shown the potential of concentration control to solve large-scale combinatorial optimization problems. However, it is still quite difficult to separate different DNA with the same length and to quantify individual DNA concentrations. To overcome these difficulties, we use DGGE and CDGE in this paper. We demonstrate that the proposed method enables us to separate different DNA with the same length efficiently, and we actually solve an instance of the shortest path problems.

  DOI：

  10.1007/bf03037359

文献信息

• Proteasome inhibitors and methods of using the same
  申请人：Bernadini Raffaella

  公开号：US20050107307A1

  公开（公告）日：2005-05-19

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以通过抑制蛋白酶体活性等方式调节细胞凋亡。这些化合物和组合物可以用于诱导细胞凋亡并治疗癌症等疾病，以及与蛋白酶体活性直接或间接相关的其他疾病。
• PROTEASOME INHIBITORS AND METHODS OF USING THE SAME
  申请人：Bernardini Raffaella

  公开号：US20090291918A1

  公开（公告）日：2009-11-26

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以调节细胞凋亡，例如通过抑制蛋白酶体活性。这些化合物和组合物可以用于诱导细胞凋亡和治疗癌症及其他与蛋白酶体活性直接或间接相关的疾病。
• Proteasome Inhibitors and Methods of Using the Same
  申请人：Bernardini Raffaella

  公开号：US20120041196A1

  公开（公告）日：2012-02-16

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以调节凋亡，例如通过抑制蛋白酶体活性。这些化合物和组合物可以用于诱导凋亡和治疗癌症以及其他与蛋白酶体活性直接或间接相关的疾病的方法。
• Proteasome Inhibitors And Methods Of Using The Same
  申请人：Cephalon, Inc.

  公开号：US20140088042A1

  公开（公告）日：2014-03-27

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以调节凋亡，例如通过抑制蛋白酶体活性。这些化合物和组合物可以用于诱导凋亡和治疗癌症和其他与蛋白酶体活性直接或间接相关的疾病的方法。
• US7576206B2
  申请人：——

  公开号：US7576206B2

  公开（公告）日：2009-08-18