4-methyl-4,5-dihydro-3H-1-benzazepine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 4-methyl-4,5-dihydro-3H-1-benzazepine
• 化学式: C₁₁H₁₃N
• 分子量: 159.23
• InChiKey: KGELTXCTRVYWOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Benzazepine compounds, conjugates, and uses thereof
  申请人：Silverback Therapeutics, Inc.

  公开号：US10428045B2

  公开（公告）日：2019-10-01

  Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds are useful, among other things, in the treating of cancer and modulating TLR8. Additionally, benzazepine compounds incorporated into a conjugate with an antibody construct are described herein.

  本文公开了用于治疗癌症等疾病的苯并氮杂卓化合物、共轭物和药物组合物。所公开的苯并氮杂卓化合物主要用于治疗癌症和调节 TLR8。此外，本文还描述了与抗体构建体结合的苯并氮杂卓化合物。
• BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF
  申请人：Silverback Therapeutics, Inc.

  公开号：US20190169164A1

  公开（公告）日：2019-06-06

  Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds are useful, among other things, in the treating of cancer and modulating TLR8. Additionally, benzazepine compounds incorporated into a conjugate with an antibody construct are described herein.