[(2S,3R,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 三唑核糖核苷和核糖核苷酸
• 英文名称: [(2S,3R,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• 化学式: C₈H₁₃N₄O₈P
• 分子量: 324.18
• InChiKey: SDWIOXKHTFOULX-PDNLFSCWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  190
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• METHODS, COMPOSITIONS, AND FORMULATIONS FOR PREVENTING OR REDUCING ADVERSE EFFECTS IN A PATIENT
  申请人：Stover Richard R.

  公开号：US20080175891A1

  公开（公告）日：2008-07-24

  The present invention provides transdermal administration of AICA riboside, or a prodrugs, analogs, or salts thereof, and/or a blood clotting inhibitor for preventing or reducing adverse side effects in a patient. The type of patient that may benefit includes a patient with decreased left ventricular function, a patient with a prior myocardial infarction, a patient undergoing non-vascular surgery, or a fetus during labor and delivery.

  本发明提供了通过经皮途径给予AICA核糖苷，或其前药、类似物或盐，和/或血液凝块抑制剂以预防或减少患者的不良副作用。可能受益的患者类型包括左心室功能减退的患者、先前发生心肌梗死的患者、接受非血管手术的患者，或分娩期间的胎儿。
• Delivery of compounds with rehydrated blood cells
  申请人：Nichols C. Timothy

  公开号：US20050025748A1

  公开（公告）日：2005-02-03

  Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells may be red blood cells or blood platelets.

  描述了携带活性剂的固定干燥血细胞，以及制备这些血细胞的方法、使用这些血细胞的方法以及含有这些血细胞的组合物。这些血细胞可以是红细胞或血小板。
• [EN] SIALOCHIMERIC COMPOUNDS<br/>[FR] COMPOSÉS SIALOCHIMÉRIQUES
  申请人：THERAPICON SRL

  公开号：WO2011064303A1

  公开（公告）日：2011-06-03

  The present invention discloses a new class of compounds that exhibit an inhibitory effect on influenza virus type A and B, which may or may not be resistant to other drugs, as well as on other types of viruses, such as flavivirus but also on protozoa and other micro-organisms, their preparation methods, pharmaceutical formulations containing them and their use as medicinal products for the treatment of various conditions caused by particular microorganisms, including viruses, bacteria and protozoa, which affect animal and human health.

  本发明公开了一类新化合物，对甲型和乙型流感病毒具有抑制作用，这些病毒可能对其他药物具有或不具有抗药性，还对其他类型的病毒，如黄病毒以及原虫和其他微生物具有抑制作用，以及它们的制备方法、含有它们的药物配方以及它们作为药用产品用于治疗各种由特定微生物引起的疾病，包括影响动物和人类健康的病毒、细菌和原虫。
• BROAD-SPECTRUM ANTIVIRAL NUCLEOSIDE DERIVATIVES
  申请人：Kalman Thomas I.

  公开号：US20210363169A1

  公开（公告）日：2021-11-25

  The disclosure relates to broad spectrum, direct acting antiviral agents. Disclosed is a group of novel nucleoside and nucleotide analogs having a 4-substituted imidazol-2-one heterocycle in place of the pyrimidine base of natural nucleic acid components and their prodrug derivatives (see Formula I).

  本公开涉及广谱、直接作用的抗病毒药物。公开了一组新颖的核苷和核苷酸类似物，其在天然核酸成分的嘧啶碱基位置上具有4-取代咪唑-2-酮杂环，以及其前药衍生物（参见公式I）。
• Novel virus proliferaton inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue
  申请人：——

  公开号：US20040235761A1

  公开（公告）日：2004-11-25

  1 wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and A has the same meaning as given in the specification. The present invention relates to a method for exhibiting a virus growth-inhibiting effect and/or a virucidal effect, in which pyrazine nucleotide analog [2] and pyrazine nucleoside analog [3z] are subjected to biotransformation, decomposed and then phosphorylated, so that they become a pyrazine nucleotide analog [1b] exhibiting the aforementioned effect. This method is useful as a method for treating virus infections. Moreover, the pyrazine carboxamide analog or a salt thereof of the present invention is useful as an agent for preventing or treating virus infections.

  本发明涉及一种展示病毒生长抑制效应和/或病毒灭活效应的方法，其中将吡嗪核苷酸类似物[2]和吡嗪核苷类似物[3z]经生物转化、分解和磷酸化，使其成为展示前述效应的吡嗪核苷酸类似物[1b]。该方法可用作治疗病毒感染的方法。此外，本发明的吡嗪羧酰胺类似物或其盐可用作预防或治疗病毒感染的药剂。其中R1、R2、R3、R4、R5、R6、R7、R8、R9和A的含义与规范中所述相同。