α-bromophenylacetic acid NHS ester | 594857-18-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-bromophenylacetic acid NHS ester
• 英文别名: 1-{[Bromo(phenyl)acetyl]oxy}pyrrolidine-2,5-dione；(2,5-dioxopyrrolidin-1-yl) 2-bromo-2-phenylacetate
• CAS: 594857-18-8
• 化学式: C₁₂H₁₀BrNO₄
• 分子量: 312.12
• InChiKey: UEARQMMURNPGJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  、 α-bromophenylacetic acid NHS ester 生成 5-[10-[[2-[(2-Bromo-2-phenylacetyl)amino]acetyl]amino]decylcarbamoyl]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
  参考文献：
  名称：

  Lipophilic electrophoretic probes

  摘要：

  本发明公开了用于标记膜的化合物、组合物和方法。其中，描述了公式G-L-E的化合物，其中G是一个亲脂性基团，L是一个可断裂的连接基团，E是一个电泳基团。这些化合物与膜相关联，并且可以通过断裂诱导基团进行断裂，从而释放可检测的电泳基团。

  公开号：

  US20040022843A1
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 alpha-溴苯乙酸 在 N,N'-二环己基碳二亚胺 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 生成 α-bromophenylacetic acid NHS ester
  参考文献：
  名称：

  Lipophilic electrophoretic probes

  摘要：

  本发明公开了用于标记膜的化合物、组合物和方法。其中，描述了公式G-L-E的化合物，其中G是一个亲脂性基团，L是一个可断裂的连接基团，E是一个电泳基团。这些化合物与膜相关联，并且可以通过断裂诱导基团进行断裂，从而释放可检测的电泳基团。

  公开号：

  US20040022843A1

文献信息

• DETECTING AND PROFILING MOLECULAR COMPLEXES
  申请人：Monogram BioSciences, Inc.

  公开号：EP1673399B1

  公开（公告）日：2017-04-05
• Detecting and profiling molecular complexes
  申请人：Chan-Yui Po-Ying

  公开号：US20080233602A1

  公开（公告）日：2008-09-25

  Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for one or more second proteins in a complex are provided. Upon binding, the cleaving probe is induced to generate an active species, such as singlet oxygen, that cleaves molecular tags attached to the binding compounds only in the local region of the cleaving probe. The released molecular tags are separated from the assay mixture and from one another to provide a readout that is related to the number and types of proteins present in the complex.
• Single Cell Analysis of Membrane Molecules
  申请人：Boone Travis

  公开号：US20090173631A1

  公开（公告）日：2009-07-09

  Interrogation of surface receptors of individual cells within a population of cell types in a single mixture is described. Each cell comprises, bound to target surface receptors on the cell, a collection of binding compositions, each comprising a distinct molecular tag. A continuous flow of cell medium containing the cells is pneumatically transported through a channel in a separation device, toward a cleavage/release zone, where specific tags correlating to each binding composition, and thus to each corresponding cell surface receptor, are released from the binding compositions on the cell surface. The method is effective to produce a separately detectable collection of tag signals for each cell.
• US7160735B2
  申请人：——

  公开号：US7160735B2

  公开（公告）日：2007-01-09
• US7255999B2
  申请人：——

  公开号：US7255999B2

  公开（公告）日：2007-08-14