(2-Allyloxy-ethyl)-benzyl-amine | 127536-05-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Allyloxy-ethyl)-benzyl-amine
• 英文别名: N-benzyl-2-prop-2-enoxyethanamine
• CAS: 127536-05-4
• 化学式: C₁₂H₁₇NO
• 分子量: 191.273
• InChiKey: AOYQCCATOKLEAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-Allyloxy-ethyl)-benzyl-amine 在 silver tetrafluoroborate 、 C₃₆H₂₆I₂N₄Pt 作用下， 以 苯 为溶剂， 反应 48.0h， 以90%的产率得到N-Benzyl-methyl-3 morpholin
  参考文献：
  名称：

  A N-heterocyclic carbene (NHC) platinum complex as pre-catalyst for the intramolecular hydroamination of olefins with secondary alkylamines and oxidative amination of ω-alkenic amines

  摘要：

  A N-heterocyclic carbene (NHC) platinum complex 3 prepared from BINAM was found to be a highly effective pre-catalyst for the intramolecular hydroamination of olefins with secondary alkylamines to give the corresponding intramolecular hydroamination products in excellent yields. The substrate scope has been carefully examined and the plausible reaction mechanism has been also proposed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.02.060
• 作为产物：
  描述：

  2-(苄亚基氨基)乙醇 在 sodium tetrahydroborate 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 3.5h， 生成 (2-Allyloxy-ethyl)-benzyl-amine
  参考文献：
  名称：

  A Convenient Synthesis of Allyl 2-Benzylaminoalkyl Ethers

  摘要：

  一系列2-(苄亚氨基)醇与烯丙基溴在四氢呋喃中存在氢化钠的条件下进行O-烯丙基化反应，得到相应的烯丙基醚，随后在甲醇中用硼氢化钠平稳还原，得到烯丙基2-苄氨基烷基醚。

  DOI：

  10.1055/s-1989-27449

文献信息

• DOBREV, ALEXANDER, SYNTHESIS (BRD),(1989) N2, C. 963-965
  作者：DOBREV, ALEXANDER

  DOI：——

  日期：——
• A Convenient Synthesis of Allyl 2-Benzylaminoalkyl Ethers
  作者：Alexander Dobrev

  DOI：10.1055/s-1989-27449

  日期：——

  The O-allylation of a series of 2-(benzylideamino)alkanols with allyl bromide in tetrahydrofuran in the presence of sodium hydride gave the corresponding allyl ethers, which were smoothly reduced with sodium borohydride in methanol to give allyl 2-benzyaminoalkyl ethers.

  一系列2-(苄亚氨基)醇与烯丙基溴在四氢呋喃中存在氢化钠的条件下进行O-烯丙基化反应，得到相应的烯丙基醚，随后在甲醇中用硼氢化钠平稳还原，得到烯丙基2-苄氨基烷基醚。
• A N-heterocyclic carbene (NHC) platinum complex as pre-catalyst for the intramolecular hydroamination of olefins with secondary alkylamines and oxidative amination of ω-alkenic amines
  作者：Rui Zhang、Qin Xu、Liang-yong Mei、Sheng-ke Li、Min Shi

  DOI：10.1016/j.tet.2012.02.060

  日期：2012.4

  A N-heterocyclic carbene (NHC) platinum complex 3 prepared from BINAM was found to be a highly effective pre-catalyst for the intramolecular hydroamination of olefins with secondary alkylamines to give the corresponding intramolecular hydroamination products in excellent yields. The substrate scope has been carefully examined and the plausible reaction mechanism has been also proposed. (C) 2012 Elsevier Ltd. All rights reserved.