2-chloro-1-(biphenyl-4-yl)ethanol | 19177-51-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-1-(biphenyl-4-yl)ethanol
• 英文别名: α-Chlormethyl-4-biphenylcarbinol；α-(chloromethyl)-4-phenylbenzyl alcohol；4-(1-hydroxy-2-chloroethyl)-biphenyl；(+)-2-chloro-1-(4'-phenylphenyl)ethanol；2-Chloro-1-(4-phenylphenyl)ethan-1-ol；2-chloro-1-(4-phenylphenyl)ethanol
• CAS: 19177-51-6
• 化学式: C₁₄H₁₃ClO
• 分子量: 232.71
• InChiKey: VBJOILSDSBKSIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-chloro-1-(biphenyl-4-yl)ethanol 在 四丁基碘化铵 、 potassium carbonate 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 1-(biphenyl-4-yl)-2-(2-methoxy-4-nitro-1H-imidazol-1-yl)ethanol
  参考文献：
  名称：

  Synthesis and antitubercular activity of monocyclic nitroimidazoles: Insights from econazole

  摘要：

  We have designed and synthesized econazole-derived nitroimidazoles to investigate the antitubercular activity of the nitroimidazole compounds. The introduction of a nitro group at the 4-position of the imidazole on econazole abolished the antitubercular activity. However, alcoholic nitroimidazoles 4 and 6 compounds were active against Mycobacterium tuberculosis (Mtb). While the MIC value of econazole was 16 mu g/mL, the MIC of 6a and 6f turned out to be 0.5 mu g/mL. In particular, the activity of 6f against non-replicating Mtb was as good as PA-824, which is currently in clinical phase II studies as an antitubercular agent. Overall, alcohol compounds 4 and 6 tend to be more active than ether compounds 5 and 7. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.128
• 作为产物：
  描述：

  2'-氯代联苯乙酮 在 甲醇 、 sodium tetrahydroborate 作用下， 反应 1.0h， 生成 2-chloro-1-(biphenyl-4-yl)ethanol
  参考文献：
  名称：

  바이시클릭니트로이미다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물

  摘要：

  本发明涉及一种双环氮咪唑衍生物或其药学上可接受的盐，其制备方法以及含有其作为有效成分的结核病预防或治疗用药学组合物，根据本发明，新型双环氮咪唑衍生物对结核杆菌在各种环境中表现出优异的抗结核功效，因此可用作结核病的预防或治疗用药学组合物。

  公开号：

  KR101650716B1

文献信息

• 바이시클릭니트로이미다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY 한국화학연구원(319980077651)

  公开号：KR101650716B1

  公开（公告）日：2016-08-24

  본 발명은 바이시클릭니트로이미다졸 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 신규한 바이시클릭니트로이미다졸 유도체는 다양한 환경에서의 결핵균에 대하여 우수한 항결핵 효능을 나타내므로, 결핵의 예방 또는 치료용 약학적 조성물로 유용할 수 있다.

  本发明涉及一种双环氮咪唑衍生物或其药学上可接受的盐，其制备方法以及含有其作为有效成分的结核病预防或治疗用药学组合物，根据本发明，新型双环氮咪唑衍生物对结核杆菌在各种环境中表现出优异的抗结核功效，因此可用作结核病的预防或治疗用药学组合物。
• Process for producing optically active halohydrin compound
  申请人：——

  公开号：US20040082820A1

  公开（公告）日：2004-04-29

  A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an &agr;-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.

  一种制备光学活性卤代醇化合物的方法，其特征在于在存在具有取代或未取代环戊二烯基基团和光学活性二胺化合物的9族过渡金属化合物的情况下进行α-卤代酮化合物的不对称氢转移还原。最好在碱存在下进行不对称氢转移还原。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE HALOHYDRIN COMPOUND
  申请人：Ajinomoto Co., Inc.

  公开号：EP1346972A1

  公开（公告）日：2003-09-24

  A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an α-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.

  一种制备光学活性卤代化合物的工艺，其特征在于包括在具有取代或未取代环戊二烯基团的第9族过渡金属化合物和光学活性二胺化合物存在下，对α-卤代酮化合物进行不对称氢转移还原。不对称氢转移还原最好在碱存在下进行。
• 10.1038/s41557-024-01551-8
  作者：Liu, Heng、Ji, Ding-Wei、Mei, Yong-Kang、Liu, Yan、Liu, Chang-Hui、Wang, Xiao-Yu、Chen, Qing-An

  DOI：10.1038/s41557-024-01551-8

  日期：——

  bioaccumulation. Urgent action is required to develop effective approaches for the reduction and reuse of HOPs. Whereas current strategies focus primarily on the degradation of HOPs, repurposing them is an alternative approach, albeit a challenging task. Here we discover that alkyl bromide can act as a catalyst for the transfer of chlorine using alkyl chloride as the chlorine source. We demonstrate

  卤化有机污染物（HOP）由于其高毒性、持久性和生物累积性，正在造成严重的环境和人类健康危机。需要采取紧急行动来制定减少和再利用 HOP 的有效方法。虽然目前的策略主要集中在 HOP 的降解上，但重新利用它们是一种替代方法，尽管这是一项具有挑战性的任务。在这里，我们发现烷基溴可以作为使用烷基氯作为氯源的氯转移的催化剂。我们证明这种方法具有广泛的底物范围，并成功地将其应用于重复使用 HOP，包括二氯二苯基三氯乙烷、六溴环十二烷、氯化石蜡、氯甲基聚苯乙烯和聚氯乙烯 (PVC)。此外，我们还表明，使用PVC和六溴环十二烷可以合成必需的非甾体抗炎药，并且我们证明PVC废料可以直接用作氯化剂。总体而言，这种方法为重新利用 HOP 提供了一种有前景的策略。
• EP1346972
  申请人：——

  公开号：——

  公开（公告）日：——