Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation
作者:Yi-Feng Wang、Kah Kah Toh、Jian-Yuan Lee、Shunsuke Chiba
DOI:10.1002/anie.201101009
日期:2011.6.20
Catalysts in a relay: A synthetic method for delivering highly substituted isoquinolines has been developed (see scheme; Cp*=C5Me5, DMF=N,N‐dimethylformamide, TEMPO=2,2,6,6‐tetramethylpiperidine‐1‐oxyl). A preliminary mechanistic study showed that the rhodium and copper cooperate synergistically in the multistep sequence.
继电器中的催化剂:已开发出一种用于合成高度取代的异喹啉的合成方法(参见方案; Cp * = C 5 Me 5,DMF = N,N-二甲基甲酰胺,TEMPO = 2,2,6,6-四甲基哌啶-1-氧基)。初步的机理研究表明,铑和铜在多步骤序列中协同协同作用。