diethyl (2-ethylphenyl)phosphonate | 15286-15-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: diethyl (2-ethylphenyl)phosphonate
• 英文别名: 1-diethoxyphosphoryl-2-ethylbenzene
• CAS: 15286-15-4
• 化学式: C₁₂H₁₉O₃P
• 分子量: 242.255
• InChiKey: XLFIWDPTZJKKTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  diethyl (2-ethylphenyl)phosphonate 、 丙烯酸乙酯 在 silver hexafluoroantimonate 、 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 copper diacetate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 15.0h， 以78%的产率得到(E)-ethyl 3-(2-(diethoxyphosphoryl)-3-ethylphenyl)acrylate
  参考文献：
  名称：

  铑（iii）催化的芳基膦酸酯的邻烯化†

  摘要：

  首次报道了铑（III）催化的芳基膦酸酯的CH H烯化反应。在这种温和而有效的过程中，膦酸酯基已成功用作新的导向基团。另外，使用膦二酰胺引导基团观察到芳基膦酸酯的单烯烃化。

  DOI：

  10.1039/c3ob41548a
• 作为产物：
  描述：

  乙基苯 、 亚磷酸三乙酯 生成 diethyl (2-ethylphenyl)phosphonate
  参考文献：
  名称：

  NIKITIN, E. V.;ROMAXIN, A. S.;PARAKIN, O. V.;ROMANOV, G. V.;KOSACHEV, I. +, DOKL. AN CCCP, 1982, 266, N 2, 402-405

  摘要：

  DOI：

文献信息

• PHOSPHO-INDOLES AS HIV INHIBITORS
  申请人：Storer Richard

  公开号：US20090163444A1

  公开（公告）日：2009-06-25

  3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.

  本文介绍了用于治疗逆转录病毒感染，尤其是HIV的3-磷酸吲哚化合物。还包括仅由3-磷酸吲哚衍生物或与一种或多种其他抗逆转录病毒药物组合而成的组合物，其制备过程以及制造包含这些化合物的药物的方法。
• Phosphoindoles as HIV inhibitors
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP1961757A1

  公开（公告）日：2008-08-27

  3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.

  本文描述了用于治疗逆转录病毒感染，特别是艾滋病毒的 3-膦酰吲哚化合物。此外，还包括由 3-膦酰吲哚衍生物单独或与一种或多种其他抗逆转录病毒药物组合而成的组合物、其制备工艺以及制造含有这些化合物的药物的方法。
• Phospho-indoles as HIV inhibitors
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP2256124A1

  公开（公告）日：2010-12-01

  3-Phosphoindonle compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.

  本文描述了用于治疗逆转录病毒感染，特别是艾滋病毒的 3-磷吲哚化合物。此外，还包括由 3-磷吲哚衍生物单独或与一种或多种其他抗逆转录病毒药物组合而成的组合物、其制备工艺以及生产含有这些化合物的药物的方法。
• POLYETHYLENE-2,6-NAPHTHALATE COMPOSITION WITH EXCELLENT BLOW MOLDABILITY, AND MOLDED PRODUCT THEREOF
  申请人：Teijin Limited

  公开号：EP3109271A1

  公开（公告）日：2016-12-28

  The object of the present invention is to provide a highly crystalline polyethylene-2,6-naphthalate composition by achieving high molecular weight of PEN, wherein the polyethylene-2,6-naphthalate composition has greatly improved blow moldability and provides molded products having excellent hue, excellent weathering resistance, and additionally excellent transparency. The above-mentioned problems can be solved by a polyethylene-2,6-naphthalate composition comprising a specific phosphoric acid which is a phosphorus compound, cobalt element derived from a cobalt compound, manganese element derived from a manganese compound, and antimony element derived from an antimony compound, wherein the content of each of the elements simultaneously satisfies the following expressions (1) to (4): 10≤Co≤30mmol% 0.50≤P/Mn≤1.28 10≤Sb≤25mmol% 0.60≤IV≤1.50dL/g

  本发明的目的是通过实现 PEN 的高分子量来提供一种高结晶性的聚 2,6-萘二甲酸乙二酯组合物，其中聚 2,6-萘二甲酸乙二酯组合物大大提高了吹塑成型性，并提供具有优异色调、优异耐候性和优异透明度的成型产品。上述问题可以通过一种聚 2,6-萘二甲酸乙二醇酯组合物来解决，该组合物包含特定的磷化合物磷酸、从钴化合物中提取的钴元素、从锰化合物中提取的锰元素和从锑化合物中提取的锑元素，其中每种元素的含量同时满足以下表达式（1）至（4）：10≤Co≤30mmol% 0.50≤P/Mn≤1.28 10≤Sb≤25mmol% 0.60≤IV≤1.50dL/g
• POLYTRIMETHYLENE TEREPHTHALATE COMPOSITION, POLYESTER FIBERS, AND METHOD FOR PRODUCING SAME
  申请人：Teijin Limited

  公开号：EP3249012A1

  公开（公告）日：2017-11-29

  A polytrimethylene terephthalate composition including a polyester having a trimethylene terephthalate unit as a main repeating unit, which satisfies all the following requirements : (a) the intrinsic viscosity is 0.50 to 1.60 dL/g; (b) titanium dioxide whose weight distribution of particles having a particle size of more than 1.0 µm is 5.0% by weight or less is contained in an amount of 0.05 to 3.0% by weight; (c) the crystallization exothermic peak top temperature is 165°C or more; and (d) the half-width of the crystallization exothermic peak is 20°C or less. In addition, the invention further encompasses a method for producing a polytrimethylene terephthalate composition using titanium dioxide that has been subjected to a wet-grinding treatment, and also a fiber obtained from the composition. The invention provides a polytrimethylene terephthalate composition, which stabilizes the process in the production of a fiber having small single-fiber fineness by melt-spinning, and is suitable for obtaining a fiber with reduced fluffing.

  一种聚对苯二甲酸三亚甲基酯组合物，包括一种以对苯二甲酸三亚甲基酯单元为主要重复单元的聚酯，该组合物满足以下所有要求：(a)固有粘度为 0.50 至 1.60 dL/g；(b)二氧化钛的重量分布为粒径大于 1.(c) 结晶放热峰顶温度为 165℃或以上；以及 (d) 结晶放热峰的半宽度为 20℃或以下。此外，本发明还包括一种使用经过湿法研磨处理的二氧化钛生产聚对苯二甲酸三甲酯组合物的方法，以及从该组合物中获得的纤维。本发明提供了一种聚对苯二甲酸三甲酯组合物，该组合物可稳定通过熔融纺丝法生产单纤维细度较小的纤维的工艺，并适用于获得绒毛较少的纤维。