1-(3-Methoxy-2-propoxypropoxy)butane

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-(3-Methoxy-2-propoxypropoxy)butane
• 英文别名: 1-(3-methoxy-2-propoxypropoxy)butane
• 化学式: C₁₁H₂₄O₃
• 分子量: 204.31
• InChiKey: UBSPJXUJTYZALJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] FLUOROPOLYMER EMULSIONS WITH BRANCHED SEMIFLUORINATED BLOCK COPOLYMER OR PHOSPHOLIPID SURFACTANT FOR THE DELIVERY OF HYDROPHOBIC DRUGS<br/>[FR] ÉMULSIONS DE FLUOROPOLYMÈRES COMPORTANT DES COPOLYMÈRES SÉQUENCÉS SEMI-FLUORÉS ET RAMIFIÉS OU UN TENSIOACTIF PHOSPHOLIPIDIQUE POUR L'ADMINISTRATION DE MÉDICAMENTS HYDROPHOBES
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2015164781A1

  公开（公告）日：2015-10-29

  The present invention provides therapeutic formulations, including therapeutic nanoemulsions, and related methods for the in vivo delivery of hydrophobic compounds, including an important class of hydrophobic anesthetics. Formulations and methods of the invention include semifluorinated block copolymers, and optionally phospholipid surfactants, capable of forming a stable nanoemulsion without the need of conventional lipid components that support bacterial and/or fungal growth(e.g., soybean oil and similar lipids). In certain embodiments, emulsion-based formulations are provided that are capable of formulating, delivering and releasing amounts of hydrophobic drugs effective for a range of clinical applications, including inducing and maintaining anesthesia in patients. In certain embodiments, emulsion-based formulations are provided that are capable of supporting controlled release, for example, over a range of rates useful for clinical applications including rapid and sustained release.

  本发明提供了治疗配方，包括治疗纳米乳液，以及相关方法，用于体内传递疏水化合物，包括一类重要的疏水麻醉剂。本发明的配方和方法包括半氟化块共聚物，以及可选择的磷脂表面活性剂，能够形成稳定的纳米乳液，而无需传统的支持细菌和/或真菌生长的脂质成分（例如大豆油和类似脂质）。在某些实施例中，提供了基于乳液的配方，能够制备、传递和释放对一系列临床应用有效的疏水药物量，包括在患者中诱导和维持麻醉。在某些实施例中，提供了基于乳液的配方，能够支持受控释放，例如，在一系列对于临床应用有用的速率范围内，包括快速和持续释放。