N-benzyl-N-cyclopropylethylenediamine | 91907-31-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N-cyclopropylethylenediamine
• 英文别名: N'-benzyl-N'-cyclopropylethane-1,2-diamine
• CAS: 91907-31-2
• 化学式: C₁₂H₁₈N₂
• 分子量: 190.288
• InChiKey: GSKTVDXUOMLCFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-benzyl-N-cyclopropylethylenediamine 在 palladium on activated charcoal 盐酸 、 氢气 作用下， 以 乙醇 为溶剂， 反应 2.5h， 生成 N-acetyl-N'-cyclopropylethylenediamine
  参考文献：
  名称：

  Synthesis and preliminary data on new selective and potent gastric prokinetic substituted benzamides

  摘要：

  A series of amino-halogen-N-[2-aminoethyl] benzamides was synthesized and evaluated for enhancing gastric emptying. Compared to metoclopramide, domperidone and bromopride, a number of compounds were shown to be more active in enhancing gastric motility (rat stomach emptying), devoid of dopaminergic D2-receptor antagonism (rat apomorphine test) and to be less toxic.

  DOI：

  10.1016/0223-5234(93)90129-3
• 作为产物：
  描述：

  N-acetyl-N'benzyl-N'-cyclopropylethylenediamine 在 盐酸 作用下， 反应 2.0h， 生成 N-benzyl-N-cyclopropylethylenediamine
  参考文献：
  名称：

  Synthesis and preliminary data on new selective and potent gastric prokinetic substituted benzamides

  摘要：

  A series of amino-halogen-N-[2-aminoethyl] benzamides was synthesized and evaluated for enhancing gastric emptying. Compared to metoclopramide, domperidone and bromopride, a number of compounds were shown to be more active in enhancing gastric motility (rat stomach emptying), devoid of dopaminergic D2-receptor antagonism (rat apomorphine test) and to be less toxic.

  DOI：

  10.1016/0223-5234(93)90129-3

文献信息

• N-cycloalkylaminoethylbenzamide derivatives, their synthesis and
  申请人：Poli Industria Chimica S.p.A.

  公开号：US05010108A1

  公开（公告）日：1991-04-23

  New N-(2-cycloalkylamino)ethyl-substituted benzamides having a powerful stimulating activity on gastric motility and with a low central anti-dopaminergic activity are described. The synthesis and the pharmaceutical preparation for therapeutical use are also described.

  本文介绍了一种具有强烈胃动力刺激活性且中枢抗多巴胺活性较低的新型N-(2-环烷基氨基)乙基取代苯甲酰胺。同时还介绍了其合成方法和制备方法，用于治疗。
• N-cycloalkylaminoethylbenzamide derivatives, their synthesis and pharmaceutical preparations
  申请人：POLI INDUSTRIA CHIMICA S.p.A.

  公开号：EP0333073A2

  公开（公告）日：1989-09-20

  New N-(2-cycloalkylamino)ethyl-substituted benzami­des having a powerful stimulating activity on the gastric motility and with a low central anti-dopaminergic activity are described. The synthesis and the pharmaceutical preparations for therapeutical use are also described.

  本研究描述了对胃动力具有强大刺激活性且中枢抗多巴胺活性较低的新型 N-（2-环烷基氨基）乙基取代苯甲酰胺。此外，还介绍了合成方法和用于治疗的药物制剂。
• US5010108A
  申请人：——

  公开号：US5010108A

  公开（公告）日：1991-04-23