4-deoxy-α-D-xylo-hexose | 141611-79-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 4-deoxy-α-D-xylo-hexose
• 英文别名: α-D-4dxylHexp；α-D-arabino-4-deoxy-hexopyranose；4-Deoxy-alpha-D-glucose；(2S,3R,4S,6S)-6-(hydroxymethyl)oxane-2,3,4-triol
• CAS: 141611-79-2
• 化学式: C₆H₁₂O₅
• 分子量: 164.158
• InChiKey: HDEMQQHXNOJATE-AZGQCCRYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  poly[β-L-Rhap-(1->4)-β-D-GlcpNAc-(1->3)-[α-D-4dxylHexp-(1->2)]-β-L-Rhap-(1->4)-β-D-GlcNAc-(1->3)] 、 乙酸酐 生成 2-乙酰氨基-2-脱氧-beta-D-吡喃葡萄糖胺 、 β-L-rhamnose 、 4-deoxy-α-D-xylo-hexose 、 4-deoxy-β-D-xylo-hexopyranose
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS<br/>[FR] COMPOSÉS ET MÉTHODES POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：UNIV WASHINGTON

  公开号：WO2011050323A1

  公开（公告）日：2011-04-28

  The present invention encompasses compounds and methods for treating urinary tract infections.

  本发明包括用于治疗尿路感染的化合物和方法。
• Compositions and Methods for Reducing Enones to Saturated Alcohols
  申请人：YALE UNIVERSITY

  公开号：US20210163384A1

  公开（公告）日：2021-06-03

  The invention relates to novel, scalable synthetic routes that allow for direct reduction of enones to the corresponding saturated alcohols. The invention relates, in certain aspects, to synthetic routes that allow for the reduction of enones to the corresponding ketones. Such reactions take place under mild conditions, are compatible with a wide range of functional groups, and expand the repertoire of existing green chemistry methodology. In certain embodiments, the reactions are run in aqueous solvent.

  本发明涉及一种新颖的可扩展的合成路线，允许将烯酮直接还原为相应的饱和醇。本发明在某些方面涉及合成路线，允许将烯酮还原为相应的酮。这样的反应在温和条件下进行，与广泛的官能团兼容，并扩展了现有绿色化学方法的技术。在某些实施例中，反应在水溶剂中进行。
• NOVEL INDOCYANINE COMPOUND, SYNTHESIS METHOD AND PURIFICATION METHOD THEREOF, DIAGNOSTIC COMPOSITION USING THE INDOCYANINE COMPOUND, AND DEVICE FOR MEASURING BIOKINETICS AND DEVICE FOR VISUALIZING CIRCULATION USING THE DIAGNOSTIC COMPOSITION
  申请人：NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY

  公开号：US20150152267A1

  公开（公告）日：2015-06-04

  The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.

  本发明旨在提供一种新型吲哚菁化合物，解决传统使用的吲哚菁绿在水或生理盐水中的溶解度、合成方法、纯化方法以及包括新型吲哚菁化合物的诊断组合物等问题。此外，还提供了一种评估新型吲哚菁化合物生物动力学的方法和测量生物动力学的设备，以及利用诊断组合物可视化循环体液（如血液）的方法和设备。还发现了一种新型吲哚菁化合物，其中近红外荧光吲哚菁分子中的疏水基团包含在环糖链环糊精的空腔中，用葡萄糖覆盖吲哚菁分子中的疏水基团，并提供了合成方法和纯化方法。此外，还发现了一种静脉注射荧光成像非肝脏器官的方法，以及评估新型吲哚菁化合物生物动力学的方法、测量生物动力学的设备，以及利用包括新型吲哚菁化合物的诊断组合物可视化循环体液（如血液）的方法和设备。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。