2-ethyl-4,6-dimethyl-3-hydroxypyridine | 1161850-58-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-ethyl-4,6-dimethyl-3-hydroxypyridine
• 英文别名: 2-Ethyl-4,6-dimethylpyridin-3-ol
• CAS: 1161850-58-3
• 化学式: C₉H₁₃NO
• 分子量: 151.208
• InChiKey: VXYVEFDYQKFPIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  丁二酸 、 2-ethyl-4,6-dimethyl-3-hydroxypyridine 以 乙醇 为溶剂， 生成 2-ethyl-4,6-dimethyl-3-hydroxypyridine succinate
  参考文献：
  名称：

  [EN] ALKYL SUBSTITUTED 3-HYDROXYPYRIDINES FOR THE TREATMENT OF DEPRESSION
  [FR] 3-HYDROXYPYRIDINES ALKYL-SUBSTITUÉES POUR LE TRAITEMENT DE LA DÉPRESSION

  摘要：

  本发明涉及使用式（I）化合物或其药学上可接受的盐，其中R1选自C1-8烷基组；R2选自C1-8烷基组；R3选自H和C1-8烷基组；R4选自C1-8烷基组，用于治疗抑郁症，优选焦虑抑郁症。

  公开号：

  WO2014012593A1
• 作为产物：
  描述：

  2-propionyl-3,5-dimethylfuran 在 氨 作用下， 以 乙醇 为溶剂， 反应 15.0h， 以67%的产率得到2-ethyl-4,6-dimethyl-3-hydroxypyridine
  参考文献：
  名称：

  [EN] SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF
  [FR] 3-HYDROXYPYRIDINES SUBSTITUÉES ET COMPOSITIONS PHARMACEUTIQUES ASSOCIÉES

  摘要：

  本发明涉及一种新型治疗化合物，其化学式为（I），其中R1选自C2-8烷基组，R2独立地选自C1-8烷基组，R3独立地选自H和C1-8烷基组，R4独立地选自C1-8烷基或其药学上可接受的盐，含有这些化合物的药物组合物，用作药物的化合物以及用于制造特定药物的化合物的用途。本发明还涉及涉及通过给予这些化合物进行治疗的方法。这些新型化合物可用于治疗伴随胰岛素受体信号功能障碍的与年龄相关的疾病。

  公开号：

  WO2009078746A1

文献信息

• [EN] SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] 3-HYDROXYPYRIDINES SUBSTITUÉES ET COMPOSITIONS PHARMACEUTIQUES ASSOCIÉES
  申请人：BIRYUKOV DMITRI VALERIEVICH

  公开号：WO2009078746A1

  公开（公告）日：2009-06-25

  The present invention relates to novel therapeutic compounds of formula (I) wherein R1 is selected from the group consisting of C2-8alkyl, R2 is independently selected from the group consisting of C1-8alkyl, R3 is independently selected from the group consisting of H and C1-8alkyl, R4 is independently selected from the group consisting of C1-8alkyl or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same, the compounds for use as medicaments, and use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds. The novel compounds are useful for the treatment of age-related disorders accompanied with dysfunctional insulin receptor signaling.

  本发明涉及一种新型治疗化合物，其化学式为（I），其中R1选自C2-8烷基组，R2独立地选自C1-8烷基组，R3独立地选自H和C1-8烷基组，R4独立地选自C1-8烷基或其药学上可接受的盐，含有这些化合物的药物组合物，用作药物的化合物以及用于制造特定药物的化合物的用途。本发明还涉及涉及通过给予这些化合物进行治疗的方法。这些新型化合物可用于治疗伴随胰岛素受体信号功能障碍的与年龄相关的疾病。
• SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Biryukov Dmitri Valerievich

  公开号：US20100261764A1

  公开（公告）日：2010-10-14

  The present invention relates to novel therapeutic compounds of formula (I) wherein R 1 is selected from the group consisting of C 2-8 alkyl, R 2 is a methyl group, R 3 is independently selected from the group consisting of H and C 1-8 alkyl, R 4 is independently selected from the group consisting of C 1-8 alkyl or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same, the compounds for use as medicaments, and use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds. The novel compounds are useful for the treatment of age-related disorders accompanied with dysfunctional insulin receptor signaling.

  本发明涉及公式（I）的新型治疗化合物，其中R1选自C2-8烷基组，R2为甲基基团，R3独立地选自H和C1-8烷基组，R4独立地选自C1-8烷基或其药学上可接受的盐，含有该化合物的制药组合物，用作药物的化合物以及用于制造特定药物的化合物的用途。本发明还涉及涉及给予该化合物的治疗方法。这些新型化合物对于治疗伴随着胰岛素受体信号失调的与年龄相关的疾病是有用的。
• SUBSTITUTED 3 -HYDROZYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：BIRYUKOV Dmitri Valerievich

  公开号：US20120270908A1

  公开（公告）日：2012-10-25

  Therapeutic compounds of formula (I) wherein R1 is selected from the group consisting of C 2-8 alkyl, R2 is independently selected from the group consisting of C 1-8 alkyl, R3 is independently selected from the group consisting of H and C 1-8 alkyl, R4 is independently selected from the group consisting of C 1-8 alkyl or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same, the compounds for use as medicaments, and use of the compounds for the manufacture of specific medicaments. Also, a method of treatment involving administration of the compounds. The compounds are useful for the treatment of age-related disorders accompanied with dysfunctional insulin receptor signaling.
• [EN] ALKYL SUBSTITUTED 3-HYDROXYPYRIDINES FOR THE TREATMENT OF DEPRESSION<br/>[FR] 3-HYDROXYPYRIDINES ALKYL-SUBSTITUÉES POUR LE TRAITEMENT DE LA DÉPRESSION
  申请人：HANDELSORT AG

  公开号：WO2014012593A1

  公开（公告）日：2014-01-23

  The present invention relates to the use of compounds of formula (I) wherein R1 is selected from the group consisting of C1-8alkyl; R2 is selected from the group consisting of C1-8alkyl; R3 is selected from the group consisting of H and C1-8alkyl; and R4 is selected from the group consisting of C1-8alkyl; or a pharmaceutically acceptable salt thereof for the treatment of depression, preferably anxious depression.

  本发明涉及使用式（I）化合物或其药学上可接受的盐，其中R1选自C1-8烷基组；R2选自C1-8烷基组；R3选自H和C1-8烷基组；R4选自C1-8烷基组，用于治疗抑郁症，优选焦虑抑郁症。