6-(methoxycarbonyl)pyridazine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(methoxycarbonyl)pyridazine-3-carboxylic acid
• 英文别名: 6-(Methoxycarbonyl)pyridazine-3-carboxylic acid；6-methoxycarbonylpyridazine-3-carboxylic acid
• 化学式: C₇H₆N₂O₄
• 分子量: 182.136
• InChiKey: UWMJHJCVUQBYRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  89.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] N-PHENYL-PYRIDINE-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION MODULATORS<br/>[FR] DÉRIVÉS DE N-PHÉNYL-PYRIDINE-2-CARBOXAMIDE ET LEUR UTILISATION COMME MODULATEURS D'INTERACTIONS PROTÉINE/PROTÉINE PD-1/PD-L1
  申请人：INCYTE CORP

  公开号：WO2017106634A1

  公开（公告）日：2017-06-22

  Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

  揭示了公式（I）的化合物，以及将这些化合物用作免疫调节剂的方法，以及包含这些化合物的药物组合物。这些化合物可用于治疗、预防或改善癌症或感染等疾病或疾病。
• N-PHENYL-PYRIDINE-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION MODULATORS
  申请人：Incyte Corporation

  公开号：EP3390361A1

  公开（公告）日：2018-10-24
• HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
  申请人：Incyte Corporation

  公开号：US20170174671A1

  公开（公告）日：2017-06-22

  Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.