(1E)-2-(4-chlorophenyl)-N-[3-(2-methylpyrimidin-4-yl)anilino]-2-oxoethanimidoyl cyanide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (1E)-2-(4-chlorophenyl)-N-[3-(2-methylpyrimidin-4-yl)anilino]-2-oxoethanimidoyl cyanide
• 化学式: C₂₀H₁₄ClN₅O
• 分子量: 375.8
• InChiKey: IEMUSDOCZXLHBG-LGUFXXKBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  91
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Nogo Receptor Binding Small Molecules to Promote Axonal Growth
  申请人：Strittmatter Stephen M.

  公开号：US20110065715A1

  公开（公告）日：2011-03-17

  The present invention provides a method for identifying compounds which modulate the interaction of Nogo and Nogo receptor (NgR). The present invention also provides compounds that modulate the interaction of Nogo and Nogo receptor (NgR), the use of such compounds and compositions in the treatment or amelioration of conditions diseases or disorders, such as spinal cord injury, traumatic brain injury, stroke, multiple sclerosis, ALS, Huntington's disease, Alzheimer's disease, Parkinson's disease, epilepsy, Schizophrenia or schizoaffective disorders.