2,3-Dihydro-4-methylbenzothiophene | 80824-38-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2,3-Dihydro-4-methylbenzothiophene
• 英文别名: 2,3-dihydro-4-methylbenzothiophen；2,3-dihydro-4-methylbenzo{b}thiophene；4-methyl-2,3-dihydro-benzo[b]thiophene；4-Methyl-2,3-dihydro-benzo[b]thiophen；4-Methyl-2,3-dihydro-1-benzothiophene
• CAS: 80824-38-0
• 化学式: C₉H₁₀S
• 分子量: 150.244
• InChiKey: SOUKKWIRJUXMME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3-Dihydro-4-methylbenzothiophene 在 双氧水 作用下， 以 溶剂黄146 为溶剂， 生成 4-methyl-2,3-dihydrobenzothiophen 1,1-dioxide
  参考文献：
  名称：

  Clark, Peter David; Clarke, Kenneth; Ewing, David F., Journal of Chemical Research, Miniprint, 1981, # 10, p. 3863 - 3883

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基苯并噻吩 、 苯 、 三氯化铝 以14%的产率得到
  参考文献：
  名称：

  CLARK, P. D.;CLARKE, K.;EWING, D. F.;SCROWSTON, R. M.;KERRIGAN, F., J. CHEM. RES. MICROFICHE, 1981, N 10, 307

  摘要：

  DOI：

文献信息

• HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US20170158680A1

  公开（公告）日：2017-06-08

  The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.

  本发明提供了一种由公式（I）表示的杂环化合物，其立体异构体，或其药用可接受的盐，其药物组合物，以及它们用于制备预防或治疗中枢神经系统疾病的药物。
• Useful indole compounds
  申请人：Bartolini Wilmin

  公开号：US20070203209A1

  公开（公告）日：2007-08-30

  Indoles having various activities, including indoles that are CRTH2 are described. The compounds are useful for treating asthma, neuropathic pain, allegic rhinitis and other disorders.

  本文描述了具有多种活性的吲哚类化合物，包括CRTH2的吲哚类化合物。这些化合物可用于治疗哮喘、神经病性疼痛、过敏性鼻炎和其他疾病。
• TETRAZOLINONE COMPOUND AND APPLICATIONS THEREOF
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150299146A1

  公开（公告）日：2015-10-22

  The compound represented by formula (1): wherein R 4 and R 5 each represents a hydrogen atom, a halogen atom, or a C1-C3 alkyl group; R 6 represents a C1-C4 alkyl group, a C3-C6 cycloalkyl group, or the like; R 7 , R 8 , and R 9 each represents a hydrogen atom, a halogen atom, or the like; R 10 represents a C1-C3 alkyl group, or the like; R 13 represents a C1-C3 alkyl group, or the like; and Q represents a phenyl group, or the like; has an excellent control effect on pests.

  式(1)所代表的化合物：其中，R4和R5分别表示氢原子、卤素原子或C1-C3烷基；R6表示C1-C4烷基、C3-C6环烷基或类似物；R7、R8和R9分别表示氢原子、卤素原子或类似物；R10表示C1-C3烷基或类似物；R13表示C1-C3烷基或类似物；Q表示苯基或类似物。该化合物对害虫有极好的控制效果。
• HETEROCYCLIC COMPOUNDS, AND PREPARATION METHOD AND USE THEREOF
  申请人：Shanghai Institute Of Materia Medica Chinese Academy of Sciences

  公开号：EP3115361A1

  公开（公告）日：2017-01-11

  Provided are heterocyclic compounds represented by formula (I), stereoisomers or pharmaceutically acceptable salts of said compounds, a pharmaceutical composition of said compounds, and an application of said compounds in the preparation of a drug for the prevention and/or treatment of a central nervous system disease.

  本发明提供了由式（I）代表的杂环化合物、所述化合物的立体异构体或药学上可接受的盐、所述化合物的药物组合物，以及所述化合物在制备预防和/或治疗中枢神经系统疾病的药物中的应用。
• HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS
  申请人：Alkermes Pharma Ireland Limited

  公开号：EP3309151A1

  公开（公告）日：2018-04-18

  Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.

  公开了式 I 的内酰胺化合物及其在治疗神经和精神疾病（包括精神分裂症、躁郁症、焦虑症和失眠症）方面的用途。