Isopropyl-[1-((E)-styryl)-but-3-enyl]-amine | 42956-15-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Isopropyl-[1-((E)-styryl)-but-3-enyl]-amine
• 英文别名: (1E)-1-phenyl-N-propan-2-ylhexa-1,5-dien-3-amine
• CAS: 42956-15-0
• 化学式: C₁₅H₂₁N
• 分子量: 215.338
• InChiKey: JTACNOXPBZSOET-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  氯丙烯镁 、 (E)-N-(3-phenylprop-2-en-1-ylidene)isopropylamine 在 1.) LnCl₃ 作用下， 生成 3-苯基己-5-烯醛 、 Isopropyl-[1-((E)-styryl)-but-3-enyl]-amine
  参考文献：
  名称：

  Regioselective addition reaction of organolanthanide reagents to α,β-unsaturated imines

  摘要：

  Organolanthanum reagents[RLaCl2] generated in situ from LaCl3 and alkyl lithium or allyl magnesium could undergo a highly regioselective 1,2-addition to N-alkyl alpha,beta-unsaturated imines, which provided a new and useful approach to synthesize allyl amines with good yields and high regioselectivity. Furthermore, for N-chiral alkyl alpha,beta-unsaturated imine, in the case of n-butyl lithium, the diastereoselectivity achieved highly 90%. (C) 1997 Elsevier Science S.A.

  DOI：

  10.1016/s0022-328x(97)00460-9

文献信息

• Regioselective addition reaction of organolanthanide reagents to α,β-unsaturated imines
  作者：Changtao Qian、Taisheng Huang

  DOI：10.1016/s0022-328x(97)00460-9

  日期：1997.12

  Organolanthanum reagents[RLaCl2] generated in situ from LaCl3 and alkyl lithium or allyl magnesium could undergo a highly regioselective 1,2-addition to N-alkyl alpha,beta-unsaturated imines, which provided a new and useful approach to synthesize allyl amines with good yields and high regioselectivity. Furthermore, for N-chiral alkyl alpha,beta-unsaturated imine, in the case of n-butyl lithium, the diastereoselectivity achieved highly 90%. (C) 1997 Elsevier Science S.A.