(7-Hydroxy-8-methyl-2-oxochromen-3-yl)carbamic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: (7-Hydroxy-8-methyl-2-oxochromen-3-yl)carbamic acid
• 英文别名: (7-hydroxy-8-methyl-2-oxochromen-3-yl)carbamic acid
• 化学式: C₁₁H₉NO₅
• 分子量: 235.19
• InChiKey: YVDZIWXCZSPBAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Coumarin based Hsp90 inhibitors with urea and ether substituents
  申请人：University of Kansas

  公开号：US10030006B2

  公开（公告）日：2018-07-24

  Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.

  提供了以下式子的化合物： 其中：提供了 R1-R4、X1、Y1 和 A 如本文所定义的化合物。还提供了这些化合物的药物组合物。在某些方面，这些化合物可用于治疗疾病或紊乱。在某些实施方案中，疾病或紊乱是增殖性疾病，如癌症。
• Coumarin based HSP90 inhibitors with urea and ether substituents
  申请人：University of Kansas

  公开号：US10745386B2

  公开（公告）日：2020-08-18

  Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.

  下列公式的化合物：.....： 其中提供了 R1-R4、X1、Y1 和 A 如本文所定义的化合物。还提供了这些化合物的药物组合物。在某些方面，这些化合物可用于治疗疾病或紊乱。在某些实施方案中，疾病或紊乱是增殖性疾病，如癌症。
• COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS
  申请人：The University of Kansas

  公开号：EP3068778A2

  公开（公告）日：2016-09-21
• [EN] COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS<br/>[FR] INHIBITEURS HSP90 À BASE DE COUMARINE À SUBSTITUANTS D'URÉE ET D'ÉTHER
  申请人：UNIV KANSAS

  公开号：WO2015070238A2

  公开（公告）日：2015-05-14

  Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.