(1-bromocyclopropyl)-bis(4-chlorophenyl)methanol | 1192024-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-bromocyclopropyl)-bis(4-chlorophenyl)methanol
• 英文别名: (1-Bromocyclopropyl)-bis(4-chlorophenyl)methanol
• CAS: 1192024-23-9
• 化学式: C₁₆H₁₃BrCl₂O
• 分子量: 372.089
• InChiKey: GSXGWXJOUBFRME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  di(4-chlorophenyl)methylenecyclopropane 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 水 、 丙酮 为溶剂， 反应 3.0h， 以89%的产率得到(1-bromocyclopropyl)-bis(4-chlorophenyl)methanol
  参考文献：
  名称：

  Halohydroxylation of alkylidenecyclopropanes using N-halosuccinimide (NXS) as the halogen source: an efficient synthesis of halocyclopropylmethanol and 3-halobut-3-en-1-ol derivatives

  摘要：

  A variety of halocyclopropyl-methanol and 3-halo-but-3-en-1-ol derivatives were prepared in moderate to excellent yields via the simple halohydroxylation reaction of alkylidenecyclopropanes with convenient and mild sources of electrophilic halogen NXS (X = I, Br, Cl, F) and H2O. A plausible mechanism for the halohydroxylation has been proposed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.146

文献信息

• Halohydroxylation of alkylidenecyclopropanes using N-halosuccinimide (NXS) as the halogen source: an efficient synthesis of halocyclopropylmethanol and 3-halobut-3-en-1-ol derivatives
  作者：Yewei Yang、Chenliang Su、Xian Huang、QingYang Liu

  DOI：10.1016/j.tetlet.2009.07.146

  日期：2009.10

  A variety of halocyclopropyl-methanol and 3-halo-but-3-en-1-ol derivatives were prepared in moderate to excellent yields via the simple halohydroxylation reaction of alkylidenecyclopropanes with convenient and mild sources of electrophilic halogen NXS (X = I, Br, Cl, F) and H2O. A plausible mechanism for the halohydroxylation has been proposed. (C) 2009 Elsevier Ltd. All rights reserved.