NΑ丹磺酰-L-色氨酸环己铵盐 | 19461-29-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: NΑ丹磺酰-L-色氨酸环己铵盐
• 英文名称: dansyl-L-tryptophan
• 英文别名: L-dansyltryptophan；Dns-L-Trp；Dansyltryptophan；N-((5-(Dimethylamino)-1-naphthalenyl)sulfonyl)-L-tryptophan；(2S)-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-3-(1H-indol-3-yl)propanoic acid
• CAS: 19461-29-1
• 化学式: C₂₃H₂₃N₃O₄S
• 分子量: 437.519
• InChiKey: XESDLBBWXMRQDN-FQEVSTJZSA-N

物化性质

• 沸点：
  697.9±65.0 °C(Predicted)
• 密度：
  1.396±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  6

SDS

Version 1.4
Regulation (EC) No 1907/2006

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1 - Product and Company Information

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Product Name NA-DANSYL-L-TRYPTOPHAN
CYCLOHEXYLAMMONIUM

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2 - Hazards Identification

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3 - Composition/Information on Ingredients

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Product Name CAS # EC no Annex I
Index Number
NA-DANSYL-L-TRYPTOPHANCYCLOHEXYLAM 19461-29-1 None None
MONIUM
Formula C23H23N3O4S·C6H13N
Molecular Weight 536,7000 AMU

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4 - First Aid Measures

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5 - Fire Fighting Measures

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6 - Accidental Release Measures

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7 - Handling and Storage

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STORAGE
Store at -20°C

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8 - Exposure Controls / Personal Protection

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9 - Physical and Chemical Properties

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pH N/A
BP/BP Range N/A
MP/MP Range N/A
SIGMA www.molbase.com
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A

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10 - Stability and Reactivity

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11 - Toxicological Information

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12 - Ecological Information

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No data available.

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13 - Disposal Considerations

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14 - Transport Information

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RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.

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15 - Regulatory Information

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Caution: Substance not yet fully tested (EU).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
Self-Classification

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16 - Other Information

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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
SIGMA www.molbase.com
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
SIGMA www.molbase.com

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为产物：
  描述：

  dansyl-L-tryptophan methyl ester 在 水 、 sodium hydroxide 作用下， 反应 12.0h， 以40%的产率得到NΑ丹磺酰-L-色氨酸环己铵盐
  参考文献：
  名称：

  An easily prepared hypersensitive water-soluble fluorescent probe for mercury(ii) ions

  摘要：

  一种超灵敏的水溶性荧光探针——丹酰基-L-色氨酸甲酯（1），可方便地制备用于检测Hg2+，在缓冲水溶液中其检测限显著提高（5 nM对比500 nM）。

  DOI：

  10.1039/b907386h

文献信息

• Direct Resolution of Optically Active Isomers on Chiral Packings Containing Ergoline Skeletons. 5. Enantioseparation of Amino Acid Derivatives
  作者：A. Messina、A. M. Girelli、M. Flieger、M. Sinibaldi、P. Sedmera、L. Cvak

  DOI：10.1021/ac950698c

  日期：1996.4.1

  alkaloid-based chiral stationary phase preparation is described. Synthesis is based on bonding the allyl derivative of terguride to mercaptopropylsilanized silica gel. The packing exhibits higher content of chiral selector, stability, reproducibility, and enantioselectivity toward amino acids compared to that previously studied. The chromatographic behavior of amino acids with different side chains and substituent

  描述了一种基于麦角生物碱的手性固定相制备的新方法。合成是基于将特固脲的烯丙基衍生物与巯基丙基硅烷化的硅胶结合。与先前研究的相比，该填料表现出更高的手性选择剂含量，稳定性，可再现性和对氨基酸的对映选择性。研究了具有不同侧链和取代基的氨基酸的色谱行为，以便更深入地了解对映鉴别机理，并确定特固利作为此类化合物的手性选择剂的局限性和强度。检查了多种因素，包括流动相参数，例如pH，离子强度，有机改性剂的含量和性质以及温度。
• A new chiral ligand exchange capillary electrophoresis system based on Zn(<scp>ii</scp>)–<scp>l</scp>-leucine complexes coordinating with β-cyclodextrin and its application in screening tyrosinase inhibitors
  作者：Yuan Su、Xiaoyu Mu、Li Qi

  DOI：10.1039/c4ra09433f

  日期：——

  hyper pigmentation in animals and enzymatic browning in food. Thus, it is of great significance to screen inhibitors of tyrosinase. In this work, a new chiral ligand exchange-capillary electrophoresis (CLE-CE) system based on the coordination effect of Zn(II)–L-leucine complexes and β-cyclodextrin (β-CD) was developed for screening the inhibitors of tyrosinase. The effects of the concentration of β-CD

  酪氨酸酶在黑色素形成中起关键作用，并且与动物体内的色素沉着过多和食物中的酶促褐变密切相关。因此，筛选酪氨酸酶抑制剂具有重要意义。在这项工作中，基于Zn（II）-L-亮氨酸复合物和β-环糊精（β-CD）的协同作用，开发了一种新的手性配体交换-毛细管电泳（CLE-CE）系统，用于筛选酪氨酸酶抑制剂。β-CD的浓度的影响，缓冲液pH的比值，大号-亮氨酸对于Zn（II），并用DNS-复杂浓度进行了调查d，大号-酪氨酸，DNS- d，大号-缬氨酸和DNS- d，L-苯丙氨酸作为被测分析物。最佳的缓冲条件包括pH值为8.2的100.0 mM硼酸，5.0 mM乙酸铵，3.0 mM Zn（II），6.0 mM L-亮氨酸和4.0 mMβ-CD。已经发现六对Dns- D，L -AA可以被基线分离，并且五对Dns- D，L- AA被部分地对映分离。然后对L-酪氨酸进行了定量分析，并以12.95μM至413.3μM的浓度获得了良好的线性（r
• Tamper-resistant authentication mark for use in product or product packaging authentication
  申请人：——

  公开号：US20040023397A1

  公开（公告）日：2004-02-05

  A method of authenticating products or packaging by analyzing key ingredients on products or on product packaging is disclosed. Light-sensitive compounds can be used to identify the product or product packaging. The product or product package may include visible or invisible ink containing a particular light-sensitive compound. One or more light-sensitive compounds and ink, if used, may be printed in one or more locations on the product or product packaging to produce an authentication mark to inhibit inadvertent or intentional removal of the mark, thereby rendering the mark tamper-resistant. The mark is sealed to isolate the mark from the environment. A device may be used to irradiate the mark and read light absorption or emission. A controller determines the authenticity of the mark by comparing the emitted or absorbed properties to a standard.

  本发明公开了一种通过分析产品或产品包装上的关键成分来鉴定产品或包装的方法。光敏化合物可用于识别产品或产品包装。产品或产品包装可包括含有特定光敏化合物的可见或不可见油墨。可以在产品或产品包装上的一个或多个位置印上一种或多种光敏化合物和墨水（如果使用），以产生验证标记，防止无意或有意去除标记，从而使标记具有防篡改功能。标记被密封起来，使标记与环境隔离。可使用一个装置照射标记并读取光吸收或发射。控制器通过将发射或吸收特性与标准进行比较来确定标记的真伪。
• Lehotay, Jozef; Hrobonova; Krupcik, Pharmazie, 1998, vol. 53, # 12, p. 863 - 865
  作者：Lehotay, Jozef、Hrobonova、Krupcik、Cizmarik

  DOI：——

  日期：——
• KOROLEVA, E. M.;MALTSEV, V. G., MEZHOTRASL. SEMIN. PO TEORII I PRAKT. ZHIDKOSTN. XROMATOGRAFII: TEZ. DOKL+
  作者：KOROLEVA, E. M.、MALTSEV, V. G.

  DOI：——

  日期：——