3-(1-Methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-ylamine | 666179-00-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃吡啶类
• 英文名称: 3-(1-Methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-ylamine
• 英文别名: 3-(1-Methylpiperidin-4-yl)furo[3,2-b]pyridin-5-amine；3-(1-methylpiperidin-4-yl)furo[3,2-b]pyridin-5-amine
• CAS: 666179-00-6
• 化学式: C₁₃H₁₇N₃O
• 分子量: 231.297
• InChiKey: WQWBEUNOWNIBOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  55.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氯-4-氟苯甲酰氯 、 3-(1-Methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-ylamine 在 吡啶 作用下， 生成 2-Chloro-4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-yl]-benzamide
  参考文献：
  名称：

  Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT1F receptor agonists

  摘要：

  Synthesis and evaluation of a series of 2,3,5- and 3,5-substituted furo[3,2-b]pyridines were undertaken in order to investigate their utility as bioisosteres of 5-HTIF receptor agonist indole analogues, 1-3. The replacement proved to be effective, providing compounds with similar 5-HTIF receptor affinity and improved selectivity when compared with the indole analogues. Through these studies we identified 4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-yl]-benzamide (5), a potent and selective 5-HTIF receptor agonist with the potential to treat acute migraine. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.09.091
• 作为产物：
  描述：

  5-Chloro-3-(1-methyl-piperidin-4-yl)-furo[3,2-b]pyridine 在 盐酸 、 tris(dibenzylideneacetone)dipalladium (0) 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 sodium t-butanolate 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 3-(1-Methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-ylamine
  参考文献：
  名称：

  Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT1F receptor agonists

  摘要：

  Synthesis and evaluation of a series of 2,3,5- and 3,5-substituted furo[3,2-b]pyridines were undertaken in order to investigate their utility as bioisosteres of 5-HTIF receptor agonist indole analogues, 1-3. The replacement proved to be effective, providing compounds with similar 5-HTIF receptor affinity and improved selectivity when compared with the indole analogues. Through these studies we identified 4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-yl]-benzamide (5), a potent and selective 5-HTIF receptor agonist with the potential to treat acute migraine. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.09.091

文献信息

• Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT1F receptor agonists
  作者：Brian M. Mathes、Kevin J. Hudziak、John M. Schaus、Yao-Chang Xu、David L. Nelson、David B. Wainscott、Suzanne E. Nutter、Wendy H. Gough、Theresa A. Branchek、John M. Zgombick、Sandra A. Filla

  DOI：10.1016/j.bmcl.2003.09.091

  日期：2004.1

  Synthesis and evaluation of a series of 2,3,5- and 3,5-substituted furo[3,2-b]pyridines were undertaken in order to investigate their utility as bioisosteres of 5-HTIF receptor agonist indole analogues, 1-3. The replacement proved to be effective, providing compounds with similar 5-HTIF receptor affinity and improved selectivity when compared with the indole analogues. Through these studies we identified 4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-yl]-benzamide (5), a potent and selective 5-HTIF receptor agonist with the potential to treat acute migraine. (C) 2003 Elsevier Ltd. All rights reserved.