(3E)-3-[(4-nitrophenyl)hydrazinylidene]-5-phenylfuran-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3E)-3-[(4-nitrophenyl)hydrazinylidene]-5-phenylfuran-2-one
• 化学式: C₁₆H₁₁N₃O₄
• 分子量: 309.281
• InChiKey: XLFLPPMEIDFKIZ-NBVRZTHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3E)-3-[(4-nitrophenyl)hydrazinylidene]-5-phenylfuran-2-one 在 一水合肼 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 以77%的产率得到4-(2-(4-nitrophenyl)hydrazono)-6-phenyl-4,5-dihydropyridazin-3(2H)-one
  参考文献：
  名称：

  Studies of Stereochemistry of 3-(Arylhydrazono)Furan-2(3Н)-Ones, Synthesis of 4-(Arylhydrazono)Pyridazin-3(1Н)-Ones

  摘要：

  The structural characteristics of 5-aryl-3-(arylhydrazono)furan-2(3De)-ones accessed via azocoupling of furan-2(3De)-ones with aryldiazonium salts were established by NMR spectroscopy (including two-dimensional NMR experiments H-1-C-13 HMQC, H-1-N-15 HMQC, H-1-C-13 HMBC, NOE) and X-ray structural analysis techniques. The reaction of synthesized compounds with hydrazine leading to the formation of six-membered heterocycles, hydrazono-substituted 4,5-dihydropyridazin-3(2De)-ones, was studied.

  DOI：

  10.1007/s10593-015-1730-5

文献信息

• Studies of Stereochemistry of 3-(Arylhydrazono)Furan-2(3Н)-Ones, Synthesis of 4-(Arylhydrazono)Pyridazin-3(1Н)-Ones
  作者：Oksana A. Maiorova、Natalya V. Babkina、Alevtina Yu. Egorova

  DOI：10.1007/s10593-015-1730-5

  日期：2015.6

  The structural characteristics of 5-aryl-3-(arylhydrazono)furan-2(3De)-ones accessed via azocoupling of furan-2(3De)-ones with aryldiazonium salts were established by NMR spectroscopy (including two-dimensional NMR experiments H-1-C-13 HMQC, H-1-N-15 HMQC, H-1-C-13 HMBC, NOE) and X-ray structural analysis techniques. The reaction of synthesized compounds with hydrazine leading to the formation of six-membered heterocycles, hydrazono-substituted 4,5-dihydropyridazin-3(2De)-ones, was studied.