4,5-difluoro-5-nitroaniline | 292145-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,5-difluoro-5-nitroaniline
• 英文别名: 3,4-Difluoro-2-nitroaniline
• CAS: 292145-76-7
• 化学式: C₆H₄F₂N₂O₂
• mdl: MFCD09258981
• 分子量: 174.107
• InChiKey: DHGFEUWOJVVCPZ-UHFFFAOYSA-N

物化性质

• 熔点：
  128 °C
• 沸点：
  318.4±37.0 °C(Predicted)
• 密度：
  1.554±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4,5-difluoro-5-nitroaniline 在 10% palladium on activated carbon 氢气 作用下， 以 乙醇 为溶剂， 反应 12.0h， 生成 4,5-二氟苯-1,2-二胺
  参考文献：
  名称：

  EP1167360

  摘要：

  公开号：

文献信息

• [EN] 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES<br/>[FR] 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YLAMIDES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2012085857A1

  公开（公告）日：2012-06-28

  The present invention relates to 3,8-diaza-bicyclo[4.2.0]oct-3-yl amide derivatives of formula (I), wherein the relative configuration of the diazabicyclooctane moiety is cis; and wherein Ar1, and Ar2 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

  本发明涉及式(I)的3,8-二氮杂双环[4.2.0]辛-3-基酰胺衍生物，其中二氮双环辛烷基的相对构型为顺式；以及其中Ar1和Ar2如描述中所述，其制备方法，其药学上可接受的盐，以及作为药物的用途，含有式(I)一个或多个化合物的药物组合物，特别是其用作促进睡眠激素受体拮抗剂。
• [EN] 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES<br/>[FR] 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YLAMIDES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2012085852A1

  公开（公告）日：2012-06-28

  The present invention relates to 3,8-diaza-bicyclo[4.2.0]oct-8-yl amide derivatives of formula (I) Formula (I) wherein the relative configuration of the diazabicyclooctane moiety is cis; and wherein Ar1, and Ar 2 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

  本发明涉及公式（I）的3,8-二氮杂双环[4.2.0]辛基酰胺衍生物。在公式（I）中，二氮杂双环辛烷基的相对构型为顺式；其中Ar1和Ar2如描述中所述，制备方法，其药学上可接受的盐，以及作为药物的用途，含有一个或多个公式（I）化合物的药物组合物，特别是其作为促进睡眠荷尔蒙受体拮抗剂的用途。
• [EN] FLUORINE CONTAINING REACTIVE DYES<br/>[FR] COLORANTS RÉACTIFS CONTENANT DU FLUOR
  申请人：DYSTAR COLOURS DEUTSCHLAND GMB

  公开号：WO2010094415A1

  公开（公告）日：2010-08-26

  The present invention claims dyestuffs of the formula (I) wherein X1, RG, R1, R2, Z1, a, b and M are defined as given in claim 1, a method for their preparation and their use.

  本发明声明了公式（I）的染料，其中X1，RG，R1，R2，Z1，a，b和M的定义如权利要求书1中所述，以及它们的制备方法和使用方法。
• OPTICAL RECORDING MEDIUM AND DYE
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP1698478A1

  公开（公告）日：2006-09-06

  To provide an optical recording medium capable of high density recording or readout of optical information by a laser beam having a short wavelength. An optical recording medium comprising a substrate and a recording layer formed on the substrate, capable of recording or readout of information by irradiation with light, wherein the recording layer contains a 7-aminocarbostyril compound of the following formula (I): in the formula (I), X is an oxygen atom or a sulfur atom, R1 is a hydrogen atom or a linear or branched alkyl group which may be substituted, R6 is a linear or branched alkyl group which may be substituted, and n=1 to 4.

  提供一种光学记录介质，能够通过短波长激光束高密度记录或读出光学信息。 一种光学记录介质，包括基底和在基底上形成的记录层，能通过光照射记录或读出信息，其中记录层含有下式（I）的 7-氨基卡波胆碱化合物： 式（I）中，X 是氧原子或硫原子，R1 是氢原子或可被取代的直链或支链烷基，R6 是可被取代的直链或支链烷基，n=1 至 4。
• Optical recording medium and dye
  申请人：Miyazawa Takashi

  公开号：US20060223003A1

  公开（公告）日：2006-10-05

  To provide an optical recording medium capable of high density recording or readout of optical information by a laser beam having a short wavelength. An optical recording medium comprising a substrate and a recording layer formed on the substrate, capable of recording or readout of information by irradiation with light, wherein the recording layer contains a 7-aminocarbostyril compound of the following formula (I): in the formula (I), X is an oxygen atom or a sulfur atom, R 1 is a hydrogen atom or a linear or branched alkyl group which may be substituted, R 6 is a linear or branched alkyl group which may be substituted, and n=1 to 4.

  提供一种光学记录介质，能够通过短波长激光束高密度记录或读出光学信息。 一种光学记录介质，包括基底和在基底上形成的记录层，能通过光照射记录或读出信息，其中记录层含有下式（I）的 7-氨基羰基吡啶化合物： 式（I）中，X 是氧原子或硫原子，R 1 是氢原子或可被取代的直链或支链烷基，R 6 是可被取代的直链或支链烷基，n=1 至 4。