1-(piperidin-1-yl)-4-p-tolyl-3-(3-(trifluoromethyl)benzyl)-9H-carbazole | 1331834-50-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1-(piperidin-1-yl)-4-p-tolyl-3-(3-(trifluoromethyl)benzyl)-9H-carbazole
• 英文别名: 4-(4-methylphenyl)-1-piperidin-1-yl-3-[[3-(trifluoromethyl)phenyl]methyl]-9H-carbazole
• CAS: 1331834-50-4
• 化学式: C₃₂H₂₉F₃N₂
• 分子量: 498.591
• InChiKey: MBRNZLWNEVQUJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  哌啶 、 2-乙酰基吲哚 、 在 indium(III) chloride 作用下， 以 乙腈 为溶剂， 反应 0.25h， 以67%的产率得到1-(piperidin-1-yl)-4-p-tolyl-3-(3-(trifluoromethyl)benzyl)-9H-carbazole
  参考文献：
  名称：

  InCl3-assisted one-pot synthesis of 1-aminocarbazoles

  摘要：

  A novel InCI3-mediated one-pot reaction leading to 1-aminocarbazoles is reported. Starting from easily available 2-acetyl-1H-indole, the reaction involves the allcylation of C-3 with a prop-2-yn-1-ol followed by a domino aminobenzannulation reaction in the presence of a secondary amine. The indium salt is most likely involved as catalyst in all three steps of the one-pot reaction. Starting from 2-acetyl-1H-indole and a series of prop-2-yn-1-ols and secondary amines a small library of products has been obtained. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.06.091

文献信息

• InCl3-assisted one-pot synthesis of 1-aminocarbazoles
  作者：Diego Facoetti、Giorgio Abbiati、Monica Dell’Acqua、Elisabetta Rossi

  DOI：10.1016/j.tet.2011.06.091

  日期：2011.9

  A novel InCI3-mediated one-pot reaction leading to 1-aminocarbazoles is reported. Starting from easily available 2-acetyl-1H-indole, the reaction involves the allcylation of C-3 with a prop-2-yn-1-ol followed by a domino aminobenzannulation reaction in the presence of a secondary amine. The indium salt is most likely involved as catalyst in all three steps of the one-pot reaction. Starting from 2-acetyl-1H-indole and a series of prop-2-yn-1-ols and secondary amines a small library of products has been obtained. (C) 2011 Elsevier Ltd. All rights reserved.