7-chloro-2-(3-fluorophenyl)-5-methyl-1H-benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 7-chloro-2-(3-fluorophenyl)-5-methyl-1H-benzimidazole
• 英文别名: 4-chloro-2-(3-fluorophenyl)-6-methyl-1H-benzimidazole
• 化学式: C₁₄H₁₀ClFN₂
• 分子量: 260.69
• InChiKey: HAXJFMWCICKPRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] BENZIMIDAZOLE COMPOUNDS, USE AS INHIBITORS OF WNT SIGNALING PATHWAY IN CANCERS, AND METHODS FOR PREPARATION THEREOF<br/>[FR] COMPOSÉS DE BENZIMIDAZOLE, UTILISATION COMME INHIBITEURS DE LA VOIE DE SIGNALISATION WNT DANS DES CANCERS ET PROCÉDÉS DE PRÉPARATION ASSOCIÉS
  申请人：SOUTHERN RES INST

  公开号：WO2017132511A1

  公开（公告）日：2017-08-03

  The present disclosure is concerned with benzimidazole compounds that are capable of inhibiting Wnt signaling and methods of treating disease states such as, for example, cancer, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.