3-Tropanyl-3,5-dichlorobenzoate | 329912-91-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Tropanyl-3,5-dichlorobenzoate
• 英文别名: (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3,5-dichlorobenzoate
• CAS: 329912-91-6
• 化学式: C₁₅H₁₇Cl₂NO₂
• 分子量: 314.2
• InChiKey: MNJNPLVXBISNSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,5-二氯苯甲酰氯 生成 3-Tropanyl-3,5-dichlorobenzoate
  参考文献：
  名称：

  FOZARD, J. R.;GITTOS, M. W.

  摘要：

  DOI：

文献信息

• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Improvements in or relating to specific 5-HT3 antagonists
  申请人：ELI LILLY AND COMPANY

  公开号：EP0307172A2

  公开（公告）日：1989-03-15

  This invention provides bicyclic carboxylic esters and amides, their pharmaceutical formulations, and a method for their use in treating migraine, emesis, gastrointestinal disorders, schizophrenia, or anxiety in mammals.

  本发明提供了双环羧酸酯和酰胺、其药物制剂以及用于治疗哺乳动物偏头痛、呕吐、胃肠道疾病、精神分裂症或焦虑症的方法。
• Method of treating nausea, vomiting, retching or any combination thereof
  申请人：Dynogen, Inc.

  公开号：US20040254171A1

  公开（公告）日：2004-12-16

  The invention relates to a method of treating nausea, vomiting, retching or any combination thereof in a subject in need of treatment. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT 3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating nausea, vomiting, retching or any combination thereof in a subject in need thereof, comprising coadministering to said subject a first amount of a 5-HT 3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount. In addition, the method of the invention comprises administering a NARI alone.

  本发明涉及一种治疗需要治疗的对象的恶心、呕吐、反胃或其任何组合的方法。该方法包括向需要治疗的受试者施用治疗有效量的化合物，该化合物具有 5-HT 3 受体拮抗剂活性和肾上腺素再摄取抑制剂（NARI）活性的化合物。本发明进一步涉及一种治疗需要治疗的受试者的恶心、呕吐、反胃或其任何组合的方法，包括向所述受试者联合施用第一量的5-HT 3 拮抗剂和第二量的 NARI，其中第一量和第二量共同构成治疗有效量或各自存在治疗有效量。此外，本发明的方法还包括单独施用一种 NARI。
• Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of neoplasia
  申请人：Masferrer L. Jaime

  公开号：US20050085477A1

  公开（公告）日：2005-04-21

  The present invention provides compositions and methods for the treatment of neoplasia in a subject. More particularly, the invention provides a combination therapy for the treatment of a neoplasia comprising the administration to a subject of a serotonin modulating agent in combination with a cyclooxygenase-2 selective inhibitor.

  本发明提供了用于治疗受试者肿瘤的组合物和方法。更具体地说，本发明提供了一种治疗肿瘤的组合疗法，包括向受试者施用5-羟色胺调节剂与环氧化酶-2选择性抑制剂。
• Agonists and antagonists of 5h3-like receptors of invertebrates as pesticides
  申请人：Trowell Charles Stephen

  公开号：US20050054680A1

  公开（公告）日：2005-03-10

  The present invention provides compositions and methods for controlling an helminth or arthropod pest. In a preferred embodiment of the invention provided herein, the compositions comprise compounds which alter the 5-HT 3 receptor of the pest. Also claimed are various esters of N-methyl 8-azabicyclo[3.2.1]octan-3-ol (tropan-3-yl esters) and an assay for identifying and/or assessing a helminth and/or arthropod control compound by determining the ability of a candidate compound to modulate the activity of a helminth or arthropod 5-HT 3 receptor.

  本发明提供了控制蠕虫或节肢动物害虫的组合物和方法。在本文提供的本发明的一个优选实施方案中，组合物包括改变 5-HT 3 受体的化合物。本发明还要求得到 N-甲基 8-氮杂双环[3.2.1]辛烷-3-醇的各种酯（托坦-3-基酯），以及通过测定候选化合物调节螺旋体或节肢动物 5-HT 3 受体的能力。