CN-9 | 137206-97-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: CN-9
• 英文别名: DMPQ；5,7-Dimethoxy-3-(4-pyridinyl)quinoline；5,7-dimethoxy-3-pyridin-4-ylquinoline
• CAS: 137206-97-4
• 化学式: C₁₆H₁₄N₂O₂
• 分子量: 266.299
• InChiKey: HBXDLZBPKJEWHZ-UHFFFAOYSA-N

物化性质

• 沸点：
  441.3±40.0 °C(Predicted)
• 密度：
  1.192±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（加热时高达1mg/ml）或水（高达30mg/ml）。

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  α-[(dimethylamino)-methylene]-4-pyridineacetaldehyde 在 溶剂黄146 作用下， 反应 10.0h， 生成 CN-9
  参考文献：
  名称：

  Singh, Baldev; Lesher, George Y., Journal of Heterocyclic Chemistry, 1991, vol. 28, # 5, p. 1453 - 1454

  摘要：

  DOI：

文献信息

• Optical Imaging Contrast Agents
  申请人：Klaveness Jo

  公开号：US20080019907A1

  公开（公告）日：2008-01-24

  The invention provides contrast agents for optical imaging of vulnerable atherosclerotic plaque in patients. The contrast agents may be used in diagnosis of vulnerable atherosclerotic plaque, for follow up of progress in disease development, for follow up of treatment of vulnerable atherosclerotic plaque and for surgical guidance. Further, the invention provides methods for optical imaging of vulnerable atherosclerotic plaque in patients.

  本发明提供了用于患者脆弱性动脉粥样硬化斑块的光学成像对比剂。这些对比剂可用于诊断脆弱性动脉粥样硬化斑块，用于随访疾病发展进展，用于随访脆弱性动脉粥样硬化斑块的治疗以及用于手术指导。此外，本发明还提供了用于患者脆弱性动脉粥样硬化斑块的光学成像方法。
• Optical Imaging Contrast Agents For Imaging Lung Cancer
  申请人：Klaveness Jo

  公开号：US20070212305A1

  公开（公告）日：2007-09-13

  The invention provides contrast agents for optical imaging of lung cancer in patients. The contrast agents may be used in diagnosis of lung cancer, for follow up of progress in disease development, for follow up of treatment of lung cancer and for surgical guidance. Further, the invention provides methods for optical imaging of lung cancer in patients.

  这项发明提供了用于患者肺癌光学成像的对比剂。这些对比剂可用于肺癌的诊断，用于随访疾病进展，用于随访肺癌治疗以及用于手术指导。此外，该发明还提供了用于患者肺癌光学成像的方法。
• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Method and apparatus for measuring protein post-translational modification
  申请人：ICAGEN, INC.

  公开号：US10577642B2

  公开（公告）日：2020-03-03

  The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The donor chemical includes a functional group selected from ester, anhydride, imide, acyl halide, and amide. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Yet another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. An additional analytical method is also used to measure either the acceptor product or the donor chemical.

  本发明包括一种分析反应的方法。该方法包括以下步骤：提供至少一种受体化学物质和至少一种供体化学物质的溶液。供体化学物质能够向受体化学物质捐献一个化学分子。溶液还包括至少一种可影响供体化学物质和受体化学物质之间反应的控制化学物质。然后对溶液进行培养，使部分受体化学物质与供体化学物质发生反应，形成受体产物。未反应的供体化学物质与受体产物分离。然后使用 X 射线荧光测量受体产物或供体化学物质。本发明的另一方面包括一种分析蛋白质功能的方法。该方法包括以下步骤：提供至少一种受体化学品和至少一种供体化学品的溶液。供体化学物质能够向受体化学物质提供一个化学分子。供体化学品包括选自酯、酸酐、酰亚胺、酰卤和酰胺的官能团。然后对溶液进行培养，使部分受体化学物质与供体化学物质发生反应，形成受体产物。未反应的供体化学物质与受体产物分离。然后使用 X 射线荧光测量受体产物或供体化学物质。本发明的另一方面包括一种分析蛋白质功能的方法。该方法包括以下步骤：提供至少一种受体化学品和至少一种供体化学品的溶液。然后对溶液进行培养，使部分受体化学物质与供体化学物质发生反应，形成受体产物。未反应的供体化学物质从受体产物中分离出来。然后使用 X 射线荧光测量受体产物或供体化学物质。还可使用另一种分析方法来测量受体产物或供体化学品。
• METHOD AND APPARATUS FOR MEASURING PROTEIN POST-TRANSLATIONAL MODIFICATION
  申请人：Caldera Pharmaceuticals, Inc.

  公开号：EP2201353A1

  公开（公告）日：2010-06-30