Calcium;2,5-dihydroxybenzenesulfonic acid;2-sulfobenzene-1,4-diolate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Calcium;2,5-dihydroxybenzenesulfonic acid;2-sulfobenzene-1,4-diolate
• 英文别名: calcium;2,5-dihydroxybenzenesulfonic acid;2-sulfobenzene-1,4-diolate
• 化学式: C12H10CaO10S2
• 分子量: 418.4
• InChiKey: QGNBTYAQAPLTMX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -0.38
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  212
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  sodium 2,5-dihydroxybenzenesulfonate 、 calcium carbonate 生成 Calcium;2,5-dihydroxybenzenesulfonic acid;2-sulfobenzene-1,4-diolate
  参考文献：
  名称：

  NOVACEK, A.;SEDLACKOVA, V.;KRAL, Z.;HORACEK, L.;SIMEK, P.

  摘要：

  DOI：

文献信息

• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• [EN] NOVEL BENZAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS<br/>[FR] NOUVEAUX DÉRIVÉS DE BENZAMIDE UTILES EN TANT QUE MODULATEURS DES CANAUX POTASSIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2009068509A1

  公开（公告）日：2009-06-04

  This invention relates to novel benzamide derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

  这项发明涉及新型苯甲酰胺衍生物，发现它们是钾通道的有效调节剂，因此是治疗对钾通道调节敏感的疾病或疾病的有价值候选药物。
• Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
  申请人：Rogers D. Robin

  公开号：US20070093462A1

  公开（公告）日：2007-04-26

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  揭示了离子液体及制备活性药物、生物、营养和能量成分的离子液体组合物的方法。还揭示了利用本文描述的组合物的方法，以克服多型性、克服溶解度和输送问题、控制释放速率、增加功能性、增强功效（协同作用）以及改善易用性和制造工艺。
• [EN] NOVEL PHENYL-ACETAMIDE AND PHENYL-PROPIONAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS<br/>[FR] NOUVEAUX DERIVES DE PHENYL-ACETAMIDE ET DE PHENYL-PROPIONAMIDE UTILES EN TANT QUE MODULATEURS DES CANAUX POTASSIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2009068557A1

  公开（公告）日：2009-06-04

  This invention relates to novel phenyl-acetamide and phenyl- propionamide derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

  这项发明涉及新型苯乙酰胺和苯丙酰胺衍生物，发现它们是钾通道的有效调节剂，因此是治疗各种对钾通道调节敏感的疾病或紊乱的有价值候选药物。
• [EN] NOVEL PYRAZOLE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRAZOLE UTILES COMME MODULATEURS DES CANAUX POTASSIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2009003921A1

  公开（公告）日：2009-01-08

  This invention relates to novel pyrazole derivatives of formula (I) that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

  该发明涉及一种新型的嘧啶酮衍生物，其化学式为（I），发现其是钾通道的有效调节剂，因此是治疗对钾通道调节敏感的疾病或疾病的有价值候选药物。