N-Acetyl-N-hexyl-acetamide | 25457-47-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Acetyl-N-hexyl-acetamide
• 英文别名: N-Acetyl-N-hexylacetamide
• CAS: 25457-47-0
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: NVAWTNQGSZYSHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Methods and compositions for modulating cell proliferation and cell death
  申请人：——

  公开号：US20040010001A1

  公开（公告）日：2004-01-15

  Methods and compositions for modulating the FGF effect on the sensitivity of malignant and normal cells to anticancer agents are provided. In particular, methods and compositions for inhibiting FGF-induced resistance to a broad spectrum of anticancer agents in solid and soft-tissue tumors, metastatic lesions, leukemia and lymphoma are provided. Preferably, the compositions include at least one FGF inhibitor in combination with a cytotoxic agents, e.g., antimicrotubule agents, topoisomerase I inhibitors, topoisomerase II inhibitors, antimetabolites, mitotic inhibitors, alkylating agents, intercalating agents, agents capable of interfering with a signal transduction pathway (e.g., g., a protein kinase C inhibitor, e.g., an anti-hormone, e.g., an antibody against growth factor receptors), an agent that promotes apoptosis and/or necrosis, an interferon, an interleukin, a tumor necrosis factor, and radiation. In other embodiments, methods and composition for protecting a cell in a subject, from one or more of killing, inhibition of growth or division or other damage caused, e.g., by a cytotoxic agent, are provided. Preferably, the method includes: administering, to the subject, an effective amount of at least one FGF agonist, thereby treating the cell, e.g., protecting or reducing the damage to the dividing cell from said cytotoxic agent.

  本研究提供了调节 FGF 对恶性和正常细胞对抗癌剂敏感性的影响的方法和组合物。特别是提供了抑制 FGF 诱导的实体和软组织肿瘤、转移性病变、白血病和淋巴瘤对多种抗癌剂的耐药性的方法和组合物。优选地，组合物包括至少一种 FGF 抑制剂与细胞毒性制剂的组合，例如抗微管制剂、拓扑异构酶 I 抑制剂、拓扑异构酶 II 抑制剂、抗代谢物、有丝分裂抑制剂、烷化制剂、插层制剂、能够干扰信号传导途径的制剂（如...、如蛋白激酶 C 抑制剂、抗激素、生长因子受体抗体）、促进细胞凋亡和/或坏死的制剂、干扰素、白细胞介素、肿瘤坏死因子和辐射。 在其他实施方案中，提供了用于保护受试者体内细胞免受杀灭、生长或分裂抑制或其他损伤（例如由细胞毒剂造成的损伤）中的一种或多种的方法和组合物。优选地，该方法包括：向受试者施用有效量的至少一种 FGF 激动剂，从而治疗细胞，例如保护或减少所述细胞毒剂对分裂细胞的损伤。
• Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy
  申请人：——

  公开号：US20040180955A1

  公开（公告）日：2004-09-16

  A method for determining a therapeutically effective amount of suramin for administering to a patient, who is to receive a cytotoxic agent, which comprises the steps of determining the circulating suramin concentration in the patient; administering suramin, if required, to establish a low circulating concentration of suramin in the patient of below about 200 &mgr;M; and administering the chemotherapeutic agent to the patient when the low circulating concentration of suramin is present in the patient. Conveniently a nomogram can be constructed for use in clinical settings with the suramin.

  一种确定治疗有效量的舒拉敏的方法，用于给将接受细胞毒性药物治疗的患者用药，该方法包括以下步骤：确定患者体内舒拉敏的循环浓度；如果需要，用舒拉敏使患者体内舒拉敏的低循环浓度低于约 200 &mgr;M；当患者体内出现舒拉敏的低循环浓度时，给患者用化疗药物。方便的是，在临床上可以用苏氨酸构建一个提名图。
• METHODS AND COMPOSITIONS FOR MODULATING CELL PROLIFERATION AND CELL DEATH
  申请人：Au, Jessie L.S.

  公开号：EP1206234A2

  公开（公告）日：2002-05-22
• EP1206234A4
  申请人：——

  公开号：EP1206234A4

  公开（公告）日：2005-06-01
• EP1429713A4
  申请人：——

  公开号：EP1429713A4

  公开（公告）日：2007-08-08