cis N,N-dimethyl-5-[4-nitrophenoxy]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-amine | 72575-45-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cis N,N-dimethyl-5-[4-nitrophenoxy]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-amine
• 英文别名: 6,7,8,9-Tetrahydro-N,N-dimethyl-5-(nitrophenyl)oxy-5H-benzocycloheptene-7-amine fumarate；(5R,7R)-N,N-dimethyl-5-(4-nitrophenoxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine
• CAS: 72575-45-2
• 化学式: C₁₉H₂₂N₂O₃
• 分子量: 326.395
• InChiKey: ASNYPHGOFQAGQM-VQIMIIECSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  58.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cis N,N-dimethyl-5-[4-nitrophenoxy]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-amine 在 二氧化铂 作用下， 以 乙醇 、 氢气 为溶剂， 反应 0.5h， 以to obtain 3.6 g of cis N,N-dimethyl-5-[4-aminophenoxy]-6,7,8,9-tetrahydro-5H-benzocycloheptene-7-amine in the form of an orange oil的产率得到cis N,N-dimethyl-5-[4-aminophenoxy]-6,7,8,9-tetrahydro-5H-benzocycloheptene-7-amine
  参考文献：
  名称：

  Novel 5H-benzocyclohepten-7-amines

  摘要：

  化合物5H-苯并环庚烯-7-胺的分子式为##STR1##其中R.sub.1选自氢和甲基组成的群，R.sub.2和R.sub.3分别选自氢、氟、氯、溴、硝基、氨基、--CF.sub.3和甲氧基组成的群，X选自氢和卤素组成的群，以及它们的非毒性、药学上可接受的酸盐，具有显著的体内外抑制血清素捕获的性质，并且可以制备。

  公开号：

  US04177292A1

文献信息

• SLOW-RELEASE FORMULATIONS OF 5-HYDROXYTRYPTOPHAN AS AN ADJUNCT TO PRO-SEROTONERGIC THERAPIES
  申请人：Duke University

  公开号：EP2629615A1

  公开（公告）日：2013-08-28
• Method for augmenting the effects of serotonin reuptake inhibitors
  申请人：Krishnan R. Ranga

  公开号：US20060142375A1

  公开（公告）日：2006-06-29

  A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount effective to treat the disorder; and concurrently administering the subject 5-hydroxytryptophan in an amount effective to enhance the activity of the serotonin enahancer, (e.g., serotonin reuptake inhibitor). In preferred embodiments the disorder is depression, anxiety, or substance abuse.
• METHOD FOR AUGMENTING THE EFFECTS OF SEROTONIN REUPTAKE INHIBITORS
  申请人：DUKE UNIVERSITY

  公开号：US20130338192A1

  公开（公告）日：2013-12-19

  A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount effective to treat the disorder; and concurrently administering the subject 5-hydroxytryptophan in an amount effective to enhance the activity of the serotonin enhancer, (e.g., serotonin reuptake inhibitor). In preferred embodiments the disorder is depression, anxiety, or substance abuse.
• US9468627B2
  申请人：——

  公开号：US9468627B2

  公开（公告）日：2016-10-18
• [EN] SLOW-RELEASE FORMULATIONS OF 5-HYDROXYTRYPTOPHAN AS AN ADJUNCT TO PRO-SEROTONERGIC THERAPIES<br/>[FR] FORMULATIONS À LIBÉRATION PROLONGÉE DE 5-HYDROXYTRYPTOPHANE EN TANT QUE COMPLÉMENT À DES THÉRAPIES PRO-SÉROTONERGIQUES
  申请人：UNIV DUKE

  公开号：WO2012054815A1

  公开（公告）日：2012-04-26

  The present invention concerns the treatment of serotonergic dyregulation disorders and/or augmentation of serotonin levels in the brain by add-on treatments to serotonin enhancers, and slow-release formulations of 5-hydroxytryptophan (5-HTP) therefor.