[(2S,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: [(2S,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
• 化学式: C₉H₁₄N₂O₁₂P₂
• 分子量: 404.16
• InChiKey: XCCTYIAWTASOJW-ZAKLUEHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  212
• 氢给体数：
  6
• 氢受体数：
  12

文献信息

• Method for detecting uracil biosynthesis inhibitors and their use as herbicides
  申请人：——

  公开号：US20020058244A1

  公开（公告）日：2002-05-16

  This invention relates to a method for identifying compounds that specifically inhibit a metabolic target site or pathway in plants. Enzymes which are specifically affected by the method of the invention include plant pyrimidine biosynthetic pathway enzymes, and particularly the enzymes involved in the conversion of orotate to uridine-5′-monophosphate (UMP). Further, the invention relates to a method for control of undesirable monocotyledenous and dicotyledenous plant species.

  这项发明涉及一种识别特定抑制植物代谢靶点或途径的化合物的方法。受该发明方法特异影响的酶包括植物嘧啶生物合成途径酶，特别是参与将小嘌呤转化为尿苷-5'-磷酸（UMP）的酶。此外，该发明涉及一种控制不良单子叶和双子叶植物物种的方法。
• [EN] HETEROCYCLIC P2Y14 RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES HÉTÉROCYCLIQUES DU RÉCEPTEUR P2Y14
  申请人：US HEALTH

  公开号：WO2019157417A1

  公开（公告）日：2019-08-15

  Disclosed are compounds of formulas (I)-(IX) for treating or preventing a disease or disorder responsive to antagonism of a P2Y14R receptor agonist in a mammal in need thereof, wherein R1-R8, X, Y, Z, X', Y', Z', and A are as defined herein, that are useful in treating an inflammatory such as asthma, cystic fibrosis, and sterile inflammation of the kidney.

  揭示了以下化合物的结构式（I）-（IX），用于治疗或预防对P2Y14R受体激动剂拮抗敏感的哺乳动物患者的疾病或紊乱，其中R1-R8、X、Y、Z、X'、Y'、Z'和A的定义如下，这些化合物可用于治疗炎症性疾病，如哮喘、囊性纤维化和肾脏的无菌性炎症。
• C1-Phostphonate Analogue of UDP-GlcNAc for Inhibition of O-GlcNAc Transferase
  申请人：SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION

  公开号：US20170022243A1

  公开（公告）日：2017-01-26

  A novel C1-phosphate analogue of uridine-5′-diphosphate (UDP)-GlcNAc as an effective OGT (O-linked N-acetylglucosamine (O-GlcNAc) transferase) inhibitor, and a preparation method for the same provides a compound having an OGT inhibitory effect that can be used as a useful tool in the studies on various vital phenomena in association with the protein modification by O-GlcNAc within cells and furthermore as a candidate substance in the treatment or research of diseases related to the protein modification by O-GlcNAc, such as cancers, diabetes, or degenerative neurological diseases.

  一种新的C1-磷酸尿苷二糖（UDP-GlcNAc）类似物，作为有效的OGT（O-连接N-乙酰葡萄糖胺转移酶）抑制剂，并提供其制备方法，提供了一种具有OGT抑制作用的化合物，可用作细胞内蛋白质修饰与O-GlcNAc相关的各种重要现象的研究工具，进一步作为治疗或研究与O-GlcNAc相关的蛋白质修饰所致疾病（如癌症、糖尿病或退行性神经疾病）的候选物质。
• Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
  申请人：Wurtman J. Richard

  公开号：US20050187182A1

  公开（公告）日：2005-08-25

  The present invention provides methods of improving a cognitive function or a neurological function, treating or ameliorating a decline in a cognitive function or a neurological function, increasing cytidine levels, or treating a neurological disorder in a subject, comprising administering a uridine, a uridine precursor, or a derivative or metabolite thereof to the subject. The invention also provides methods of improving neural function, comprising contacting the neuron with a uridine, a uridine precursor, or a derivative or metabolite thereof.

  本发明提供了改善认知功能或神经功能、治疗或改善认知功能或神经功能下降、增加胞苷水平或治疗受试者神经系统疾病的方法，包括向受试者给予脲苷、脲苷前体或其衍生物或代谢物。本发明还提供了改善神经功能的方法，包括使用脲苷、脲苷前体或其衍生物或代谢物与神经元接触。
• Compositions containing uridine and choline, and methods utilizing same
  申请人：Wurtman Dick

  公开号：US20060069061A1

  公开（公告）日：2006-03-30

  The present invention is directed to methods of improving cognitive and neurological functions and increasing synthesis and release of neurotransmitters and membrane synthesis by neural cells and brain cells, comprising administering a composition comprising a uridine and a choline.

  本发明涉及一种改善认知和神经功能，增加神经细胞和脑细胞合成和释放神经递质和膜合成的方法，包括给予含有尿嘧啶和胆碱的组合物。