[(2S,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: [(2S,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• 化学式: C₉H₁₃N₂O₉P
• 分子量: 324.18
• InChiKey: DJJCXFVJDGTHFX-ZAKLUEHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  166
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Method for detecting uracil biosynthesis inhibitors and their use as herbicides
  申请人：——

  公开号：US20020058244A1

  公开（公告）日：2002-05-16

  This invention relates to a method for identifying compounds that specifically inhibit a metabolic target site or pathway in plants. Enzymes which are specifically affected by the method of the invention include plant pyrimidine biosynthetic pathway enzymes, and particularly the enzymes involved in the conversion of orotate to uridine-5′-monophosphate (UMP). Further, the invention relates to a method for control of undesirable monocotyledenous and dicotyledenous plant species.

  这项发明涉及一种识别特定抑制植物代谢靶点或途径的化合物的方法。受该发明方法特异影响的酶包括植物嘧啶生物合成途径酶，特别是参与将小嘌呤转化为尿苷-5'-磷酸（UMP）的酶。此外，该发明涉及一种控制不良单子叶和双子叶植物物种的方法。
• CHEMOENZYMATIC SYNTHESIS OF HEPARIN AND HEPARAN SULFATE ANALOGS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20140235575A1

  公开（公告）日：2014-08-21

  The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.

  本发明提供了一种一锅多酶法，用于从简单糖起始材料制备UDP糖。该发明还提供了一种一锅多酶法，用于从简单糖起始材料制备寡糖。
• METHOD FOR THE SOLID PHASE-BASED PRODUCTION OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES
  申请人：Meier Chris

  公开号：US20120116067A1

  公开（公告）日：2012-05-10

  The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to perform the immobilization on a solid phase. A subsequent reaction with corresponding nucleophiles results in the desired phosphate-bridged nucleoside conjugates, which can then again be cleaved from the solid phase-bound linker.

  本发明涉及一种制备磷酸桥联核苷酸结合物的方法。该方法首先制备环状芳基核苷酸，然后添加连接剂，用于在固相上进行固定。随后与相应的亲核试剂反应，得到所需的磷酸桥联核苷酸结合物，然后可以从固相结合的连接剂中再次裂解出来。
• Nuclease resistant double-stranded ribonucleic acid
  申请人：Vornlocher Hans-Peter

  公开号：US20060094678A1

  公开（公告）日：2006-05-04

  This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.

  本发明涉及改性的双链寡核糖核酸(dsRNA)，其在细胞和生物液中具有改善的稳定性，以及制备和鉴定具有改善稳定性的dsRNA的方法，以及使用dsRNA抑制目标基因的表达或功能。
• Acylated uridine and cytidine and uses thereof
  申请人：Pro Neuron, Inc.

  公开号：US20020035086A1

  公开（公告）日：2002-03-21

  The invention relates to compositions comprising acyl derivatives of cytidine and uridine. The invention also relates to methods of treating hepatopathies, diabetes, heart disease, cerebrovascular disorders, Parkinson's disease, infant respiratory distress syndrome and for enhancement of phospholipid biosynthesis comprising administering the acyl derivatives of the invention to an animal.

  本发明涉及包含胞苷和尿苷的酰基衍生物的组合物。本发明还涉及将本发明的酰基衍生物用于治疗肝病、糖尿病、心脏病、脑血管疾病、帕金森病、婴儿呼吸窘迫综合症和增强磷脂生物合成的方法，包括将本发明的酰基衍生物给动物使用。