2,2'-Dichloro-4,4'-bis-trifluoromethyl-biphenyl | 135227-06-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-Dichloro-4,4'-bis-trifluoromethyl-biphenyl
• 英文别名: 5,5'-Bis-trifluoromethyl-2,2'-dichlorobiphenyl；2-chloro-1-[2-chloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethyl)benzene
• CAS: 135227-06-4
• 化学式: C₁₄H₆Cl₂F₆
• 分子量: 359.098
• InChiKey: JWKTZOCSEMZILI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  锂,(3-氟-4-甲基苯基)- 、 1-lithio-2-chloro-5-(trifluoromethyl)benzene 生成 3-fluoro-4-methyl-2'-chloro-5'-(trifluoromethyl)biphenyl 、 2,2'-Dichloro-4,4'-bis-trifluoromethyl-biphenyl
  参考文献：
  名称：

  "Kinetic" higher order cyanocuprates: applications to biaryl synthesis

  摘要：

  DOI：

  10.1021/ja00021a049

文献信息

• Process for preparing carbazoles
  申请人：Dow Global Technologies LLC

  公开号：US10246415B2

  公开（公告）日：2019-04-02

  A process for preparing one or more carbazoles comprising (a) contacting one or more compounds represented by formula (1) below with diboron reagents in the presence of PdCl2(dppf) to form one or more 2,2′-dichlorobiaryl represented by formula (2) below; and (b) contacting the one or more 2,2′-dichlorobiaryls with one or more H2N—Y compounds, in the presence of one or more palladium containing catalytic components; thereby forming one or more carbazoles represented by formula (3) below is provided.

  一种制备一种或多种咔唑的工艺，包括(a)在PdCl2(dppf)存在下，将一种或多种下式(1)代表的化合物与二硼试剂接触，形成一种或多种下式(2)代表的2,2′-二氯叔丁基；和(b)在一种或多种含钯催化组分存在下，使一种或多种 2，2′-二氯芳基与一种或多种 H2N-Y 化合物接触，从而形成一种或多种如下式(3)所代表的咔唑。
• [EN] PROCESS FOR PREPARING CARBAZOLES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE CARBAZOLES
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2018013067A1

  公开（公告）日：2018-01-18

  A process for preparing one or more carbazoles comprising (a) contacting one or more compounds represented by formula (1) below with diboron reagents in the presence of PdCl2(dppf) to form one or more 2,2'-dichlorobiaryl represented by formula (2) below; and (b) contacting the one or more 2,2'-dichlorobiaryls with one or more H2N-Y compounds, in the presence of one or more palladium containing catalytic components; thereby forming one or more carbazoles represented by formula (3) below is provided.
• "Kinetic" higher order cyanocuprates: applications to biaryl synthesis
  作者：Bruce H. Lipshutz、Konstantin Siegmann、Emiliano Garcia

  DOI：10.1021/ja00021a049

  日期：1991.10