4-Methyl-7-(phenylacetamido)coumarin | 104145-34-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-Methyl-7-(phenylacetamido)coumarin
• 英文别名: N-(4-methyl-2-oxochromen-7-yl)-2-phenylacetamide
• CAS: 104145-34-8
• 化学式: C₁₈H₁₅NO₃
• 分子量: 293.3
• InChiKey: UQUMDDZAFRUNFQ-UHFFFAOYSA-N

物化性质

• 溶解度：
  1.1 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  7-氨基-4-甲基香豆素 、 苯乙酰氯 生成 4-Methyl-7-(phenylacetamido)coumarin
  参考文献：
  名称：

  SCHEPER, THOMAS;WEISS. , MARTINA;SCHUGERL, KARL

  摘要：

  DOI：

文献信息

• Water-soluble activatable molecular probes, intermediates for the synthesis thereof and associated detection methods
  申请人：ECOLE NORMALE SUPERIEURE DE LYON

  公开号：US10179929B2

  公开（公告）日：2019-01-15

  The invention provides probes with formula (I): in which: X1═NH, O, or S; X2═O or S; SE is a labile group, which may be eliminated under the action of a stimulus that may in particular be the presence of an enzyme, a chemical compound, or a physicochemical characteristic of the medium in which the probe is located; A is an aromatic group that, following cleavage of the C(X2)—O bond in aqueous solution, leads to the liberation of a chromophore or a fluorophore, R represents a hydrogen atom or -(L)n-GP, in which n is equal to 0 or 1, L is a linker arm, and GP is a hydrosolubilizing group; as well as their physiologically acceptable salts, solvates, or hydrates. The invention also provides intermediates for the synthesis thereof and detection methods employing them.

  本发明提供了式 (I) 的探针： 其中 X1═NH、O 或 S；X2═O 或 S；SE 为易变基团，在刺激物的作用下可被消除，刺激物尤其可能是酶的存在、化合物或探针所在介质的物理化学特性；R 代表氢原子或-(L)n-GP，其中 n 等于 0 或 1，L 是连接臂，GP 是水溶性基团； 以及它们生理上可接受的盐、溶液或水合物。本发明还提供了用于合成它们的中间体以及使用它们的检测方法。
• SCHEPER, THOMAS;WEISS. , MARTINA;SCHUGERL, KARL
  作者：SCHEPER, THOMAS、WEISS. , MARTINA、SCHUGERL, KARL

  DOI：——

  日期：——
• LIGHT ACTIVATED SHAPE MEMORY CO-POLYMERS
  申请人：CORNERSTONE RESEARCH GROUP, INC.

  公开号：EP1799771A2

  公开（公告）日：2007-06-27
• Light Activated Shape Memory Co-Polymers
  申请人：Tong Hung Tat

  公开号：US20080021166A1

  公开（公告）日：2008-01-24

  The present discovery uses monomers which contain reversible photo-crosslinkable groups in addition to primary polymerizable groups. The mechanical properties of these materials and the reversibility of the photo-activated shape memory effect demonstrate the effectiveness of using photo-irradiation to effect change in modulus and shape memory effect. In the preferred embodiment the reaction mixture includes a photo-reactive monomer comprising a photo reactive group and a polymerizable group; a second monomer, which is more preferably a mixture of monomers, which are acrylate based; a multi-functional crosslinking agent, preferably 1,6 hexanediol diacrylate (HDODA); an initiator, preferably a free radical initiator; and a fifth, optional, component which is a modifying polymer. The mixture of the second monomer, crosslinking agent, and initiator comprise the base polymer matrix into which the photo-reactive monomer is incorporated. The polymeriziable group of the photo reactive monomer allows the photo reactive monomer to polymerize with the base polymer matrix.
• WATER-SOLUBLE ACTIVATABLE MOLECULAR PROBES, INTERMEDIATES FOR THE SYNTHESIS THEREOF AND ASSOCIATED DETECTION METHODS
  申请人：ECOLE NORMALE SUPERIEURE DE LYON

  公开号：US20170159100A1

  公开（公告）日：2017-06-08

  The invention provides probes with formula (I): in which: X 1 ═NH, O, or S; X 2 ═O or S; SE is a labile group, which may be eliminated under the action of a stimulus that may in particular be the presence of an enzyme, a chemical compound, or a physicochemical characteristic of the medium in which the probe is located; A is an aromatic group that, following cleavage of the C(X 2 )—O bond in aqueous solution, leads to the liberation of a chromophore or a fluorophore, R represents a hydrogen atom or -(L)n-GP, in which n is equal to 0 or 1, L is a linker arm, and GP is a hydrosolubilizing group; as well as their physiologically acceptable salts, solvates, or hydrates. The invention also provides intermediates for the synthesis thereof and detection methods employing them.