4-[(1R)-1-hydroxypropyl]-2-methoxyphenol | 210555-52-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-[(1R)-1-hydroxypropyl]-2-methoxyphenol
• CAS: 210555-52-5
• 化学式: C₁₀H₁₄O₃
• 分子量: 182.219
• InChiKey: HDHXMZVCZFGENR-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  diethylzinc 、 香草醛 在 N-((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)furan-2-carboxamide 、 盐酸 、 水 作用下， 以 正己烷 、 甲苯 为溶剂， 生成 4-[(1R)-1-hydroxypropyl]-2-methoxyphenol 、 4-[(1S)-1-hydroxypropyl]-2-methoxyphenol
  参考文献：
  名称：

  Chiral amide from (1S,2R)-(+)-norephedrine alkaloid in the enantioselective addition of diethylzinc to aryl and heteroaryl aldehydes

  摘要：

  Chiral amide synthesized from (1S,2R)-(+)-norephedrine and furoic acid was found to catalyze the enantioselective ethylation of aromatic and heteroaromatic aldehydes to secondary alcohols with 99.8% enantioselectivity at 0 degrees C without the addition of a promoter such as titanium tetraisopropoxide. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.07.011

文献信息

• Chiral amide from (1S,2R)-(+)-norephedrine alkaloid in the enantioselective addition of diethylzinc to aryl and heteroaryl aldehydes
  作者：Nallamuthu Ananthi、Umesh Balakrishnan、Ajayan Vinu、Katsuhiko Ariga、Sivan Velmathi

  DOI：10.1016/j.tetasy.2009.07.011

  日期：2009.8

  Chiral amide synthesized from (1S,2R)-(+)-norephedrine and furoic acid was found to catalyze the enantioselective ethylation of aromatic and heteroaromatic aldehydes to secondary alcohols with 99.8% enantioselectivity at 0 degrees C without the addition of a promoter such as titanium tetraisopropoxide. (c) 2009 Elsevier Ltd. All rights reserved.