potassium;hydride

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属有机物
• 英文名称: potassium;hydride
• 化学式: HK
• 分子量: 40.1063
• InChiKey: OCFVSFVLVRNXFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.88
• 重原子数：
  1
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

毒理性

• 副作用

Dermatotoxin - 皮肤烧伤。

Dermatotoxin - Skin burns.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

反应信息

• 作为反应物：
  描述：

  potassium;hydride 、 2-(R)-(tert-butoxycarbonylmethyl)-4-methylpentanoic acid 在 正戊烷 、 四氢呋喃 、 氩 、 甲基甲基硫代甲砜 、 氯化铵 、 硫酸 、 碳酸氢钠 、 乙醚 、 sodium hydrogensulfite 、 sodium hydroxide 、 magnesium sulfate 作用下， 以 四氢呋喃 为溶剂， 反应 52.67h， 以to give 4 as a yellow liquid (0.141 δH, 15%)的产率得到4-i-butyldihydrofuran-2(3H)-one
  参考文献：
  名称：

  Method of treating cartilage damage

  摘要：

  本发明涉及一种通过给予GABA类似物（例如，公式1中的化合物及其药学上可接受的盐），其中R1是氢或直链或支链低碳基，n为4至6的整数，来预防或治疗软骨损伤的方法。

  公开号：

  US20020072533A1
• 作为试剂：
  描述：

  4-(2,2-dimethyl-1-oxopropyl)-benzamide 、 4-(2,2-dimethyl-1-oxopropyl)-benzoyl chloride 、 、 在 potassium;hydride 、 正己烷 、 甲基叔丁基醚 、 氯化钠 、 magnesium sulfate 、 crude product 、 silica 、 氯仿 、 异丙醇 、 Dcm mtbe 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以from methylene chloride/t-butyl methyl ether, yielding the title product (mp 132°-134° C.)的产率得到4-(2,2-dimethyl-1-oxopropyl)-N-[4-(2,2-dimethyl-1-oxopropyl) benzoyl]-benzamide
  参考文献：
  名称：

  Benzoic acid derivatives as antidiabetic agents

  摘要：

  化学式为 ##STR1## 的化合物，其中R是CH.sub.3 (CH.sub.2).sub.m，A和B是氢、键或--(CH.sub.2).sub.n，X是 ##STR2## m为0、1、2或3，n为1、2或3，R.sub.1是氢或低碳基，Y是--OH、--OR.sub.2或--NR.sub.3 R.sub.4，其中R.sub.2、R.sub.3和R.sub.4是氢或未取代或取代的烷基、芳基和芳烷基取代基。

  公开号：

  US05378728A1

文献信息

• Substituted monocyclic CGRP receptor antagonists
  申请人：Wood Michael R.

  公开号：US20070265225A1

  公开（公告）日：2007-11-15

  Compounds of formula I: (wherein variables A 1 , A 2 , A 3 , A 4 , m, n, J, Q, R 4 , E a , E b , E c , R 6 , R 7 , R e , R f , R PG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  公式I的化合物：（其中变量A1，A2，A3，A4，m，n，J，Q，R4，Ea，Eb，Ec，R6，R7，Re，Rf，RPG和Y如本文所述），它们是CGRP受体拮抗剂，可用于治疗或预防涉及CGRP的疾病，如偏头痛。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物和组合物在预防或治疗涉及CGRP的疾病方面的用途。
• Method for preparing polyorganosiloxanes (pos) by polycondensation/redistribution of oligosiloxanes in the presence of a strong base and strong bases used
  申请人：Baceiredo Antoire

  公开号：US20050080215A1

  公开（公告）日：2005-04-14

  The invention concerns the synthesis of silicone by anionic polymerisation of cyclic organosiloxane oligomers in the presence of a slightly nucleophilic strong base. The invention aims at providing novel strong base catalysts, more efficient in terms of solubility in the silicones, with hydrolysis stability strength and polymerising capacity. To achieve this, the invention provides for the use of ylides derived from aminophosphonium such as for example that of formula: [Me3N)3P—CHMe2]+, MeO or derived from phosphoranylidenes such as that of formula: [Me3P—HC=Pme3]+, t-BuO. The invention also concerns strong base catalysts as novel products.

  本发明涉及在微弱亲核强碱的存在下通过环状有机硅氧烷低聚物的阴离子聚合来合成硅。该发明旨在提供新型的强碱催化剂，其在硅烷中的溶解度更高、具有水解稳定性和聚合能力更强。为达到此目的，本发明提供了从氨基膦盐衍生的叶立德，例如式[Me3N)3P—CHMe2]+，MeO或从膦烯衍生的叶立德，例如式[Me3P—HC=Pme3]+，t-BuO的使用。本发明还涉及作为新型产品的强碱催化剂。
• Spirocyclic amides as cannabinoid receptor modulators
  申请人：Hagmann K. William

  公开号：US20050239828A1

  公开（公告）日：2005-10-27

  Novel compounds of structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as psychotropic drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinsons disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as, the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

  结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，并可用于治疗、预防和抑制由CB1受体介导的疾病。本发明的化合物可用作精神药物，用于治疗精神病、记忆障碍、认知障碍、偏头痛、神经病、神经炎性疾病（包括多发性硬化症和吉兰-巴雷综合征）及病毒性脑炎、脑血管意外和头部创伤的炎症后遗症、焦虑症、压力、癫痫、帕金森氏症、运动障碍和精神分裂症。这些化合物还可用于治疗物质滥用障碍、肥胖症或进食障碍，以及哮喘、便秘、慢性肠假性梗阻和肝硬化的治疗。
• Transition metal compound, polymerization catalyst using same and
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：US05596054A1

  公开（公告）日：1997-01-21

  There are disclosed a transition metal compound of the general formula RMX.sub.a-1 L.sub.b (R is as a .pi. ligand, a fused polycyclic cyclopentadienyl group in which at least one of many-membered rings to which cyclopentadienyl groups are fusedly bonded is a saturated ring, M is a transition metal, X is a .sigma. ligand, L is a Lewis base, a is the valency of M, and b is 0, 1 or 2); a polymerization catalyst for styrene, etc. comprising the above transition metal, preferably further comprising an oxygen atom containing compound ionic compound or organoboron compound and optionally a Lewis base; and a process for producing a polymer of a compound containing an ethylenically unsaturated double bond or an acetylenic polymer, especially a syndiotactic polystyrene by using the above polymerization catalyst. The catalyst is particularly effectivive for producing highly syndiotactic polystyrene minimized in residual metals amounts at a low cost in enhanced efficiency.

  公开了一种具有一般式RMX.sub.a-1L.sub.b的过渡金属化合物（其中R为.pi.配体，是一个融合的多环环戊二烯基团，其中至少一个与环戊二烯基团融合的多环环是饱和环，M是过渡金属，X是.sigma.配体，L是路易斯碱，a是M的价数，b为0、1或2）；一种聚合催化剂，用于苯乙烯等，包括上述过渡金属，最好还包括含氧原子的化合物离子或有机硼化合物，以及可选的路易斯碱；以及使用上述聚合催化剂制备含有乙烯基不饱和双键或乙炔基聚合物的聚合物的方法，特别是使用上述聚合催化剂生产高度对映异构的聚苯乙烯，其在增强效率的同时，最小化残留金属的数量，并且成本较低。
• Process for making 4,4'-diketo-carotenoids
  申请人：ROCHE VITAMINS, INC.

  公开号：US20010018544A1

  公开（公告）日：2001-08-30

  A process for the manufacture of a symmetrical, terminally ring-substituted polyenes by reacting a polyene di(O,O-dialkyl acetal) with a cyclic dienol ether in the presence of a Lewis or Brönsted acid, hydrolyzing the condensation product resulting therefrom and cleaving off alcohol under basic or acidic conditions from the polyene derivative produced at this stage. The novel cyclic dienol ethers, as well as, novel intermediates resulting from the condensation and additional intermediates in this process form further aspects of the invention. The final products are primarily carotenoids, which find corresponding use, e.g., as colorings and pigments for foodstuffs, animal products, etc.

  一种制造对称、端基环替代聚烯烃的方法，通过在路易斯酸或布朗斯特德酸的存在下，将聚烯烃二(O,O-二烷基缩醛)与环状二烯醇醚反应，水解所得到的缩合产物，并在碱性或酸性条件下从此阶段产生的聚烯烃衍生物中剥离醇。新颖的环状二烯醇醚以及由缩合产物和该过程中的其他中间体产生的新颖中间体，形成了该发明的进一步方面。最终产品主要是类胡萝卜素，可以相应地用作食品、动物产品等的着色剂和颜料。