[(2R,3S,5R)-5-[2,4-二氧代-5-(三氟甲基)嘧啶-1-基]-3-羟基四氢呋喃-2-基]甲基(羟基-膦酰氧基磷酰)磷酸氢酯 | 345-03-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 中文名称: [(2R,3S,5R)-5-[2,4-二氧代-5-(三氟甲基)嘧啶-1-基]-3-羟基四氢呋喃-2-基]甲基(羟基-膦酰氧基磷酰)磷酸氢酯
• 中文别名: [4-[2-(二甲氨基)乙氧基]-2-羟基苯基](4-methylphenyl)酮盐酸
• 英文名称: 5-Trifluormethyl-2'-deoxyuridin-5'-triphosphat
• 英文别名: α,α,α-trifluoro-O^5'-(tetrahydroxy-[1]triphosphoryl)-thymidine；5-Trifluoromethyl-2'-deoxyuridine 5'-triphosphate；[[(2R,3S,5R)-5-[2,4-dioxo-5-(trifluoromethyl)pyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 345-03-9
• 化学式: C₁₀H₁₄F₃N₂O₁₄P₃
• 分子量: 536.143
• InChiKey: VSXILDJQEIBHQR-RRKCRQDMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  239
• 氢给体数：
  6
• 氢受体数：
  17

文献信息

• Sample preparation method
  申请人：Oxford Nanopore Technologies Ltd.

  公开号：US10669578B2

  公开（公告）日：2020-06-02

  The invention relates to an improved method for characterising a template polynucleotide. The method involves using a polymerase to prepare a modified polynucleotide which makes it easier to characterise than the template polynucleotide.

  本发明涉及一种表征模板多核苷酸的改进方法。该方法包括使用聚合酶制备修饰的多核苷酸，使其比模板多核苷酸更容易表征。
• Methods and compositions for backscattering interferometry
  申请人：Base Pair Biotechnologies, Inc.

  公开号：US11078489B2

  公开（公告）日：2021-08-03

  The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions, particularly to methods and compositions for enhancing BSI utilizing label-free aptamers, and more particularly to methods and compositions for enhancing BSI utilizing high conformational change aptamers, which may change in conformation when the aptamers bind to their target molecules.

  本发明涉及在检测生物分子相互作用时增强背散射干涉测量法（BSI）的方法和组合物，尤其涉及利用无标记适配体增强 BSI 的方法和组合物，更具体地说，涉及利用高构象变化适配体增强 BSI 的方法和组合物，当适配体与目标分子结合时，其构象可能发生变化。
• SAMPLE PREPARATION METHOD
  申请人：Oxford Nanopore Technologies Limited

  公开号：EP3108010A1

  公开（公告）日：2016-12-28
• METHODS AND COMPOSITIONS FOR BACKSCATTERING INTERFEROMETRY
  申请人：Base Pair Biotechnologies, Inc.

  公开号：US20190119681A1

  公开（公告）日：2019-04-25

  The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions, particularly to methods and compositions for enhancing BSI utilizing label-free aptamers, and more particularly to methods and compositions for enhancing BSI utilizing high conformational change aptamers, which may change in conformation when the aptamers bind to their target molecules.
• US9963706B2
  申请人：——

  公开号：US9963706B2

  公开（公告）日：2018-05-08