Azapetine hydrochloride | 65-15-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: Azapetine hydrochloride
• 英文别名: 6-prop-2-enyl-5,7-dihydrobenzo[d][2]benzazepine;hydrochloride
• CAS: 65-15-6
• 化学式: C17H18ClN
• 分子量: 271.8
• InChiKey: PAGNTBKVOFUKLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.28
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  3.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• OPHTHALMIC USE OF ALPHA ADRENERGIC BLOCKING AGENTS
  申请人：Galin, Miles A.

  公开号：EP1255540A1

  公开（公告）日：2002-11-13
• US6730691B1
  申请人：——

  公开号：US6730691B1

  公开（公告）日：2004-05-04
• [EN] OPHTHALMIC USE OF ALPHA ADRENERGIC BLOCKING AGENTS<br/>[FR] UTILISATION OPHTALMIQUE D'AGENTS BLOQUANTS ADRENERGIQUES ALPHA
  申请人：GALIN MILES A

  公开号：WO2001058438A1

  公开（公告）日：2001-08-16

  Disclosed are methods and compositions for inhibiting undesirable visual anomalies commonly experienced by individuals who have undergone refractive eye surgery, including photophobia, glare, secondary images and haloing. In particular, the disclosure provides for topically applying an ophthalmic solution to the eye wherein the ophthalmic solution contains a therapeutically effective amount of one or more alpha adrenergic blocking agents, preferably thymoxamine. The disclosure further provides for an ophthalmic solution containing one or more alpha adrenergic blocking agents in a physiologically acceptable carrier, which can be administered to a subject at an effective dose to be therapeutically effective in concentration and rate of release. An ophthalmic solution for inhibiting one or more visual anomalies experienced by an individual who has undergone refractive eye surgery containing a therapeutically effective amount of one or more alpha adrenergic blocking agents in combination with one or more anti-irritant agents and/or one or more anti-inflammatory agents is also disclosed.