1,5-bis[(E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1,5-bis[(E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
• 化学式: C22H12Cl4N2O4
• 分子量: 510.1
• InChiKey: YYZPXBXVBQSBDG-IJIVKGSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Method for identifying compound for inhibiting an activity of a histone lysine demethylase
  申请人：NATIONAL TSING HUA UNIVERSITY

  公开号：US11279966B2

  公开（公告）日：2022-03-22

  A method for identifying a compound that inhibits an activity of a histone lysine demethylase, in which the compound interacts with three sites of a pocket of the histone lysine demethylase generated by using a computer program, an alpha-ketoglutarate (AKG), a methylated lysine, and a NIQ.

  识别一种抑制组蛋白赖氨酸去甲基酶活性的化合物的方法，其中所述化合物与通过计算机程序生成的组蛋白赖氨酸去甲基酶的口袋中的三个位点相互作用，所述口袋包括α-酮戊二酸(AKG)、甲基化赖氨酸和NIQ。
• METHOD FOR IDENTIFYING COMPOUND FOR INHIBITING AN ACTIVITY OF A HISTONE LYSINE DEMETHYLASE
  申请人：NATIONAL TSING HUA UNIVERSITY

  公开号：US20150267241A1

  公开（公告）日：2015-09-24

  The present invention relates to a method for identifying a compound that inhibits an activity of a histone lysine demethylase.
• COMPOSITIONS AND METHODS FOR USE OF EFLORNITHINE AND DERIVATIVES AND ANALOGS THEREOF TO TREAT CANCERS, INCLUDING GLIOMAS
  申请人：Orbus Therapeutics, Inc.

  公开号：US20190133985A1

  公开（公告）日：2019-05-09

  Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. Compositions and methods can include eflornithine or a derivative or analog of eflornithine, together with other agents such as conventional anti-neoplastic agents for treatment of glioma, inhibitors of polyamine transport, polyamine analogs, or S-adenosylmethionine decarboxylase inhibitors. Eflornithine or derivatives or analogs thereof can also be used to treat a range of non-glioma malignancies, including both malignancies of the central nervous system and other malignancies.
• US9890434B2
  申请人：——

  公开号：US9890434B2

  公开（公告）日：2018-02-13