[hydroxy-[[(2S,3R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: [hydroxy-[[(2S,3R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
• 化学式: C₁₀H₁₇N₂O₁₄P₃
• 分子量: 482.17
• InChiKey: NHVNXKFIZYSCEB-GJMOJQLCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  239
• 氢给体数：
  6
• 氢受体数：
  14

文献信息

• [EN] COMPOSITIONS AND METHODS FOR SYNTHESIS OF PHOSPHORYLATED MOLECULES<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE SYNTHÈSE DE MOLÉCULES PHOSPHORYLÉES
  申请人：UNIV CALIFORNIA

  公开号：WO2019195494A1

  公开（公告）日：2019-10-10

  The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

  这项发明提供了合成磷酸化有机化合物的组合物和方法，包括核苷三磷酸。
• [EN] ISOQUINOLINE COMPOUNDS HAVING ANTIINFECTIVE ACTIVITY<br/>[FR] COMPOSES ISOQUINOLINE PRESENTANT UNE ACTIVITE ANTI-INFECTIEUSE
  申请人：GENESOFT INC

  公开号：WO2002100832A1

  公开（公告）日：2002-12-19

  Isoquinoline compounds having the formula where R1, R2, Y, m, n, and Z are as defined herein, bind to the minor groove of DNA and have antifungal and antibacterial activity.

  具有以下公式的异喹啉化合物，其中R1、R2、Y、m、n和Z的定义如本文所述，结合DNA的小沟，并具有抗真菌和抗细菌活性。
• APTAMER INHIBITION OF THROMBUS FORMATION
  申请人：Wang Binghe

  公开号：US20110144187A1

  公开（公告）日：2011-06-16

  Boronic acid-modified DNA-based aptamers can be selected to recognize fibrinogen through binding at a glycosylation site and thus are useful for probing the effect of glycosylation pattern changes on the ability for fibrinogen to mediate blood coagulation. In addition, the aptamers of the disclosure also have anticoagulation effects due to their binding to fibrinogen and its cleavage product fibrin. The present disclosure, therefore, encompasses methods for inhibiting fibrin coagulation with an aptamer capable of specifically binding to a glycosylation site of fibrinogen or fibrin. The disclosure further provides oligonucleotide aptamers comprising at least one nucleotide having a boronic acid thereon, where the aptamer is capable of selectively binding to a glycosylation site of fibrinogen, or the derivative thereof.

  硼酸修饰的基于DNA的适配体可以被选择用于识别纤维蛋白原，通过在糖基化位点进行结合，因此对于探究糖基化模式变化对于纤维蛋白原介导血液凝固能力的影响非常有用。此外，本公开的适配体由于与纤维蛋白原及其裂解产物纤维素的结合具有抗凝作用。因此，本公开涵盖了使用能够特异性结合纤维蛋白原或纤维素的糖基化位点的适配体抑制纤维蛋白凝固的方法。本公开还提供了包含至少一个具有硼酸的核苷酸的寡核苷酸适配体，其中该适配体能够选择性地结合到纤维蛋白原或其衍生物的糖基化位点。
• NUCLEOTIDES AND APTAMERS CONTAINING BORONIC ACID GROUPS HAVING BIASED BINDING TO GLYCOSYLATED PROTEINS, AND USES THEREOF
  申请人：Wang Binghe

  公开号：US20130184160A1

  公开（公告）日：2013-07-18

  The present disclosure encompasses oligonucleotide aptamers selectively binding a target glycosylated polypeptide or protein, and having biased affinity for the glycan through a boronic acid linked to a nucleosidic base of a nucleotide(s). The disclosure further encompasses methods for isolating an aptamer(s) selectively binding a target glycosylated polypeptide, where, from a population of randomized oligonucleotides that have at least one nucleotide having a boronic acid label linked to a base, is selected a first subpopulation of aptamers binding to the target glycosylated polypeptide or protein. This subpopulation is then amplified without using boronic acid-modified TTP, and amplification products not binding to a target glycosylated polypeptide or protein are selected. The second subpopulation of aptamers is then amplified using boronic acid-modified TTP to provide a population of boronic acid-modified aptamers capable of selectively binding to a glycosylation site of a target polypeptide or protein. Other aspects of the disclosure encompass methods for the use of the modified aptamers to detect glycosylated species of a polypeptide or protein.

  本公开涵盖了寡核苷酸适配体，其通过与含有硼酸基团的核苷酸的核苷酸（s）相连，对靶向糖基化的多肽或蛋白质具有偏向性亲和力。本公开还涵盖了用于分离选择性结合目标糖基化多肽的适配体（s）的方法，其中从随机化寡核苷酸的群体中选择绑定目标糖基化多肽或蛋白质的第一亚群适配体。然后，在不使用硼酸修饰的TTP的情况下扩增该亚群，选择不与目标糖基化多肽或蛋白质结合的扩增产物。然后，使用硼酸修饰的TTP扩增第二亚群适配体，以提供能够选择性结合到目标多肽或蛋白质的糖基化位点的硼酸修饰适配体的群体。本公开的其他方面涵盖了使用修饰的适配体检测糖基化的多肽或蛋白质的物种的方法。
• Modified labeled nucleotides and polynucleotides and methods of preparing, utilizing and detecting same
  申请人：ENZO BIOCHEM, INC.

  公开号：EP0097373A2

  公开（公告）日：1984-01-04

  Nucleotides and polynucleotides, including DNA, are chemically modified or labeled so as to be capable of ready detection when attached to and/or incorporated in nucleic acid material.

  核苷酸和多核苷酸（包括 DNA）经过化学修饰或标记，当附着在核酸材料上和/或掺入核酸材料中时，可随时进行检测。