(4R,12bS)-9-methoxy-3-methyl-2,4,4a,5,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (4R,12bS)-9-methoxy-3-methyl-2,4,4a,5,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.4
• InChiKey: MLISXUQVRWYXAH-QPDIMZNGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Carbohydrate conjugates to prevent abuse of controlled substances
  申请人：Mickle Travis

  公开号：US20070197451A1

  公开（公告）日：2007-08-23

  The invention provides a “street-safe” version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.
• DENDRITIC ENCAPSULATION OF ACTIVE AGENTS
  申请人：Piccariello Thomas

  公开号：US20090036553A1

  公开（公告）日：2009-02-05

  A pharmaceutical composition comprising an active agent bound to a scaffold for dendritic encapsulation wherein said scaffold is covalently or non-covalently attached to a polysaccharide. More specifically, the invention is directed to active agent complexes or conjugates which utilize dendritic encapsulation alone or in combination with other delivery systems to improve and target active agent release.
• US8133881B2
  申请人：——

  公开号：US8133881B2

  公开（公告）日：2012-03-13