Isaxonine phosphate | 65606-21-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Isaxonine phosphate
• 英文别名: phosphoric acid;N-propan-2-ylpyrimidin-2-amine
• CAS: 65606-21-5
• 化学式: C7H14N3O4P
• 分子量: 235.18
• InChiKey: CXEBHWXMQKIKPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.37
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• AGENTS FOR TREATING NEUROPHATHY
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0257102A1

  公开（公告）日：1988-03-02

  A medicinal composition comprising a pyrimidine compound represented by following general formula (I), wherein R' represents a hydrogen atom, an acyl group having 2 to 4 carbon atoms, an alkoxycarbonyl group having 2 to 5 carbon atoms, an alkoxycarbonylmethyl group having 3 to 5 carbon atoms a benzyl group, a 3,4-dimethoxybenzoyl group or a 3,4-methylenedioxybenzyl group; R2 represents a hydrogen atom, an amino group, a monoalkylamino group having 1 to 4 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or an alkoxycarbonyl group having 2 to 4 carbon atoms; R3 represents a hydrogen atom, an alkoxycarbonyl group having 2 to 4 carbon atoms, a dialkylaminocarbonyl group having 1 to 9 carbon atoms in each alkyl moiety, an alkoxy group having 1 to 5 carbon atoms or a hydroxyethyl group, or R2 and R3 may be taken together to form a 4- to 7-membered carbocyclic or heterocyclic ring containing N, 0 or S as a hetero atom together with the carbon atom to which R2 and R3 ar bound: and R4 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkylthio group having 1 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof is disclosed. These active compounds show activities of promoting growth of neural cells, forming neurites and restoring kinetic functions, thus being useful as agents for treating diseases of peripheral and central nerves.

  一种药物组合物，包含由以下通式(I)代表的嘧啶化合物，其中 R'代表氢原子、具有 2 至 4 个碳原子的酰基、具有 2 至 5 个碳原子的烷氧羰基、具有 3 至 5 个碳原子的烷氧羰甲基、苄基、3,4-二甲氧基苯甲酰基或 3,4-亚甲二氧基苄基；R2 代表氢原子、氨基、具有 1 至 4 个碳原子的单烷基氨基、具有 1 至 5 个碳原子的烷氧基或具有 2 至 4 个碳原子的烷氧羰基；R3 代表氢原子、具有 2 至 4 个碳原子的烷氧羰基、每个烷基中具有 1 至 9 个碳原子的二烷基氨基羰基、具有 1 至 5 个碳原子的烷氧基或羟乙基，或 R2 和 R3 可结合在一起形成 4 至 7 元碳环或杂环，其中 N、0 或 S 作为杂原子与 R2 和 R3 所结合的碳原子一起：和 R4 代表氢原子、1 至 4 个碳原子的烷基或 1 至 4 个碳原子的烷硫基，或其药学上可接受的盐。这些活性化合物具有促进神经细胞生长、形成神经元和恢复动力功能的活性，因此可作为治疗周围神经和中枢神经疾病的药物。
• Pyrimidines or their pharmaceutically acceptable salts thereof
  申请人：MITSUI PHARMACEUTICALS, INC.

  公开号：EP0305184A1

  公开（公告）日：1989-03-01

  Compounds of formula where X is -NR¹R² or SR⁴; Y is amino optionally substituted by alkyl; Z is methyl substituted by alkoxy carbonyl or alkoxycarbonyl or Y and Z together may form a divalent group -X-Y- of formula . The compounds are useful in the treatment if neurological diseases of the pheripheral and central nervous systems of animals.

  式中化合物 其中 X 是-NR¹R²或 SR⁴；Y 是任选被烷基取代的氨基；Z 是被烷氧羰基或烷氧羰基取代的甲基，或 Y 和 Z 可共同形成式中的二价基团-X-Y-。 .这些化合物可用于治疗动物外周和中枢神经系统的神经疾病。
• Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0379806A2

  公开（公告）日：1990-08-01

  2,6-di-, 2,4,6-, 2,5,6-tri- or 2,4,5,6-tetra-substituted pyrimidines, and 2,6-di-substituted pyridines. These compounds are useful for treatment of neurological deseases.

  2,6-二、2,4,6-、2,5,6-三或 2,4,5,6-四取代的嘧啶，以及 2,6-二取代的吡啶。这些化合物可用于治疗神经系统疾病。
• PYRIMIDINE COMPOUND AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0489925A1

  公开（公告）日：1992-06-17

  A pyrimidine compound represented by general formula (I), pharmaceutically acceptable salts thereof, and a drug containing the same for treating neural diseases, wherein X represents substituted or cyclic amino and Y represents substituted amino or substituted carbonyl. These compounds have activities of promoting the growth of nerve cells and the formation and extension of neurites, so that they are useful in treating various neural diseases.

  通式(I)代表的嘧啶化合物、其药学上可接受的盐类以及含有相同成分的用于治疗神经疾病的药物，其中 X 代表取代的或环状氨基，Y 代表取代的氨基或取代的羰基。这些化合物具有促进神经细胞生长以及神经元的形成和延伸的活性，因此可用于治疗各种神经疾病。
• Pyrimidines and their pharmaceutical acceptable salts and their use as medicines
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0612746A1

  公开（公告）日：1994-08-31

  2-Substituted pyrrelo[2,3-d]pyrimidines are useful for the treatment of neurological diseases.

  2-取代的吡咯并[2,3-d]嘧啶可用于治疗神经系统疾病。