Grisaldon | 8014-03-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Grisaldon
• 英文别名: methyl 4-hydroxybenzoate;propyl 4-hydroxybenzoate
• CAS: 8014-03-7
• 化学式: C18H20O6
• 分子量: 332.3
• InChiKey: SMYHRJOQEVSCKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.14
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• AMINO ACID SALTS OF PROSTAGLANDINS
  申请人：DeLong Mitchell A.

  公开号：US20100105775A1

  公开（公告）日：2010-04-29

  The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.

  本发明涉及新型氨基酸前列腺素盐及其制备和使用方法。
• [EN] B-LYMPHOCYTE SPECIFIC AMATOXIN ANTIBODY CONJUGATES<br/>[FR] CONJUGUÉS D'ANTICORPS D'AMATOXINE SPÉCIFIQUES DE LYMPHOCYTES B
  申请人：HEIDELBERG PHARMA RES GMBH

  公开号：WO2021074261A1

  公开（公告）日：2021-04-22

  The present application relates to a conjugate comprising an amatoxin, a target-binding moiety wherein the target is CD20, i.e., a CD20-binding moiety, and optionally a linker linking said amatoxin and said CD20-binding moiety. The invention further relates to the synthesis of said conjugate. In addition, the invention relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of B-cell and/or lymphoma associated diseases and/or malignancies.

  本申请涉及一种共轭物，包括一种阿马氧甙、一种靶向结合基团，其中靶向是CD20，即CD20结合基团，以及可选的连接剂，连接所述阿马氧甙和所述CD20结合基团。本发明还涉及所述共轭物的合成。此外，本发明涉及一种药物组合物，包括这样的共轭物，特别是用于治疗B细胞和/或淋巴瘤相关疾病和/或恶性肿瘤。
• [EN] VAGINAL DELIVERY OF BISPHOSPHONATES<br/>[FR] ADMINISTRATION DE DIPHOSPHONATES PAR VOIE VAGINALE
  申请人：UMD INC

  公开号：WO2002009631A1

  公开（公告）日：2002-02-07

  Devices, methods, and compositions for vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the vagina using a medicated intravaginal device comprising a bisphosphonate composition formulated for transvaginal delivery. A method for treatment of osteoporosis and related bone and skeleton diseases, for prevention of bone breakdown and loss of bone mass and strength by intravaginal administration of bisphosphonates to the vagina and transvaginal delivery of bisphosphonates to the general circulation.

  本发明涉及用于阴道交付双磷酸盐的装置、方法和组合物。使用含有为经阴道递送配制的双磷酸盐组合物的医用阴道装置，将双磷酸盐定向递送至阴道。通过将双磷酸盐经阴道给药并经阴道递送至全身循环，治疗骨质疏松症及相关骨骼疾病，预防骨质破坏和骨量和强度的丧失。
• Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
  申请人：Orphan Medical Inc.

  公开号：EP1316309A1

  公开（公告）日：2003-06-04

  Disclosed are formulations of gamma-hydroxybutyrate in an acqueous medium that are resistant to microbial growth . Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with thesc stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal;, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

  所公开的是γ-羟基丁酸盐在水介质中的制剂，这种制剂能够抵抗微生物的生长。还公开了γ-羟基丁酸的制剂，这些制剂还能防止转化为GBL。本发明公开了使用 GHB 的稳定制剂治疗睡眠障碍（包括嗜睡症）的方法。本发明还提供了治疗酒精和鸦片制剂戒断、生长激素水平降低、颅内压增高和病人身体疼痛的方法。
• Compositions comprising cyclohexylamines and aminoadamantanes
  申请人：Merz Pharma GmbH & Co. KGaA

  公开号：EP2289489A2

  公开（公告）日：2011-03-02

  The invention is directed to formulations of pharmaceutical compounds, such as the Cyclohexylamines and Aminoadamantanes which have antimicrobial properties. In particular, it is directed to aqueous based formulations with reduced amounts of preservatives which allow safe and convenient administration and flexible dosing and which, in the case of oral formulations, are easy to swallow. Optionally, the compositions contain components that provide the requisite stability and shelf life while reducing or avoiding incrustation of the composition around the container closure which leads to leaks and difficulty in opening the container.

  本发明涉及具有抗菌特性的药物化合物制剂，如环己基胺和氨基金刚烷。本发明特别针对水基制剂，减少了防腐剂的用量，使用药安全方便，剂量灵活，在口服制剂的情况下，易于吞咽。可选的是，这些组合物含有的成分可提供必要的稳定性和保质期，同时减少或避免组合物在容器封口周围结壳，导致泄漏和难以打开容器。