2-hydroxymethyl-but-3-enenitrile | 412320-60-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-hydroxymethyl-but-3-enenitrile
• 英文别名: 2-Hydroxymethyl-but-3-ennitril；2-hydroxymethyl-3-butene nitrile；2-(Hydroxymethyl)but-3-enenitrile
• CAS: 412320-60-6
• 化学式: C₅H₇NO
• 分子量: 97.1167
• InChiKey: PZWRVBPJHVSRTK-UHFFFAOYSA-N

物化性质

• 沸点：
  237.3±20.0 °C(Predicted)
• 密度：
  1.008 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxymethyl-but-3-enenitrile 在 sodium hydroxide 、 palladium on activated charcoal 、 乙醇 作用下， 生成 2-乙基丙烯酸
  参考文献：
  名称：

  Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and TI-201 SPECT imaging

  摘要：

  A 58-year-old man, who had biopsy-proven cardiac sarcoidosis, underwent Tl-201 and I-123 MIBG cardiac scintigraphy. Although no perfusion defect was identified by Tl-201, mild heterogeneity of I-123 MIBG uptake was present in the myocardium. The denervated but viable myocardium was demonstrated in the heart with sarcoidosis. Cardiac sympathetic nerve function was impaired in cardiac sarcoidosis, slightly improved with steroid therapy. I-123 MIBG scintigraphy may be useful to assess extent of myocardial involvement and response to therapy.

  DOI：

  10.1007/bf02988246
• 作为产物：
  描述：

  2-氯-3-丁烯-1-醇 、 氰化钠 在 乙醇 、 水 作用下， 生成 2-hydroxymethyl-but-3-enenitrile
  参考文献：
  名称：

  US2488913

  摘要：

  公开号：

文献信息

• Method of producing hexamethylene diamine from butadiene
  申请人：Degussa AG

  公开号：US20030212298A1

  公开（公告）日：2003-11-13

  The invention relates to the production of hexamethylene diamine from butadiene. The method comprises the successively performed stages of: (i) a catalytic epoxidation of butadiene to 1,2-epoxy-3-butene; (ii) a basically catalyzed addition of hydrogen cyanide to butadiene monoxide to form a reaction mixture containing 3-hydroxy-4-pentene nitrile (3HPN) and 2-hydroxymethyl-3-butene nitrile (2HMBN); (iii) an acidically catalyzed dehydration of the cyanohydrines 3HPN and 2HMBN of stage (ii) to cis/trans-pentadiene nitrile (PDN); (iv) a basically catalyzed addition of the products of stage (iii) to form cis/trans-1,4-dicyanobutene-1 and -2 (DCB); and (v) a catalytic hydrogenation of the isomeric cis/trans-1,4-dicyanobutene of stage (iv) to hexamethylene diamine.

  该发明涉及从丁二烯生产己二胺。该方法包括依次执行的阶段：(i) 催化环氧化丁二烯生成1,2-环氧-3-丁烯；(ii) 基本催化氢氰酸加到丁二烯单氧化物上形成含3-羟基-4-戊烯腈（3HPN）和2-羟甲基-3-丁烯腈（2HMBN）的反应混合物；(iii) 酸性催化脱水氰醇3HPN和2HMBN（第ii阶段）形成顺/反-戊二烯腈（PDN）；(iv) 基本催化将第(iii)阶段产物加到形成顺/反-1,4-二氰丁烯-1和-2（DCB）；以及(v) 催化氢化第(iv)阶段的顺/反-1,4-二氰丁烯异构体生成己二胺。
• US2488913
  申请人：——

  公开号：——

  公开（公告）日：——
• Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and TI-201 SPECT imaging
  作者：Shinro Matsuo、Yasuyuki Nakamura、Toshiki Matsui、Tetsuya Matsumoto、Masahiko Kinoshita

  DOI：10.1007/bf02988246

  日期：2001.8

  A 58-year-old man, who had biopsy-proven cardiac sarcoidosis, underwent Tl-201 and I-123 MIBG cardiac scintigraphy. Although no perfusion defect was identified by Tl-201, mild heterogeneity of I-123 MIBG uptake was present in the myocardium. The denervated but viable myocardium was demonstrated in the heart with sarcoidosis. Cardiac sympathetic nerve function was impaired in cardiac sarcoidosis, slightly improved with steroid therapy. I-123 MIBG scintigraphy may be useful to assess extent of myocardial involvement and response to therapy.