6-Chlor-3H-imidazo<4,5-c>pyridazin | 6584-26-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-Chlor-3H-imidazo<4,5-c>pyridazin
• 英文别名: 3-Chloro-7H-imidazo[4,5-c]pyridazine；3-chloro-5H-imidazo[4,5-c]pyridazine
• CAS: 6584-26-5
• 化学式: C₅H₃ClN₄
• 分子量: 154.559
• InChiKey: XWNKHKFVVGKLJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
  申请人：Almirall, S.A.

  公开号：EP2463289A1

  公开（公告）日：2012-06-13

  New imidazo[1,2-b]pyridazine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  揭示了具有化学结构为式（I）的新咪唑并[1,2-b]吡啶嗪衍生物；以及它们的制备方法，包含它们的药物组合物以及它们作为Janus激酶（JAK）抑制剂在治疗中的用途。
• [EN] IMIDAZO [1,2-B] PYRIDAZINE AND IMIDAZO [4,5-B] PYRIDINE DERIVATIVES AS JAK INHIBITORS<br/>[FR] DÉRIVÉS D'IMIDAZO[1,2-B]PYRIDAZINE ET D'IMIDAZO[4,5-B]PYRIDINE EN TANT QU'INHIBITEURS DES JAK
  申请人：ALMIRALL SA

  公开号：WO2012069202A1

  公开（公告）日：2012-05-31

  New imidazo[1,2-b]pyridazine and imidazo[4,5-b]pyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  揭示了具有化学结构式（I）的新咪唑并[1,2-b]吡啶嗪和咪唑并[4,5-b]吡啶衍生物；以及它们的制备方法、包含它们的药物组合物以及它们作为Janus激酶（JAK）抑制剂在治疗中的用途。
• IMIDAZO [1,2-B] PYRIDAZINE AND IMIDAZO [4,5-B] PYRIDINE DERIVATIVES AS JAK INHIBITORS
  申请人：Gonzalez Rodriguez Jacob

  公开号：US20130309200A1

  公开（公告）日：2013-11-21

  New imidazo[1,2-b]pyridazine and imidazo[4,5-b]pyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  本发明公开了具有化学结构式（I）的新的咪唑[1,2-b]吡啶嗪和咪唑[4,5-b]吡啶衍生物，以及它们的制备方法、含有它们的药物组合物和它们作为Janus激酶（JAK）抑制剂在治疗中的应用。
• IMIDAZO [1,2-B]PYRIDAZINE AND IMIDAZO [4,5-B]PYRIDINE DERIVATIVES AS JAK INHIBITORS
  申请人：Almirall S.A.

  公开号：EP2643321A1

  公开（公告）日：2013-10-02
• US4670438A
  申请人：——

  公开号：US4670438A

  公开（公告）日：1987-06-02