[1-(4-氯苯基)环丁基]甲胺盐酸盐 | 252984-78-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: [1-(4-氯苯基)环丁基]甲胺盐酸盐
• 英文名称: [1-(4-Chlorophenyl)cyclobutyl]methanamine;hydrochloride
• CAS: 252984-78-4
• 化学式: C₁₁H₁₄ClN*ClH
• 分子量: 232.153
• InChiKey: GYOHTACFVOBQFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.14
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  对氯苯乙腈 在 盐酸 、 sodium tetrahydroborate 、 potassium hydroxide 作用下， 以 甲醇 、 乙醚 、 水 、 二甲基亚砜 、 异丙醇 为溶剂， 反应 21.0h， 生成 [1-(4-氯苯基)环丁基]甲胺盐酸盐
  参考文献：
  名称：

  A Study and Identification of Potential By-Products of Sibutramine

  摘要：

  In the synthesis and process development of sibutramine (9), the isolation and characterization of two potential by-products namely heptane dinitriles (4a-b) and bis-cyclobutyl alkylamine (10) have been studied, The key steps in the synthesis of sibutramine which have contributed to the formation of above by-products are cycloalkylation of 4-chlorophenyl acetonitrile (1) and tandem Grignard reduction on 1-(4-chlorophenyl) cyclobutyl carbonitrile (3).

  DOI：

  10.1021/op980093t

文献信息

• INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP)
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2485735A1

  公开（公告）日：2012-08-15
• US8759357B2
  申请人：——

  公开号：US8759357B2

  公开（公告）日：2014-06-24
• [EN] INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP)<br/>[FR] INHIBITEURS DE PROTÉINES DE LIAISON AUX ACIDES GRAS (FABP)
  申请人：SCHERING CORP

  公开号：WO2011043994A1

  公开（公告）日：2011-04-14

  The present invention relates to novel heterocyclic compounds as Fatty Acid Binding Protein (FABP) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the present invention is shown below:
• A Study and Identification of Potential By-Products of Sibutramine
  作者：G. Om Reddy、M. R. Sarma、B. Chandrasekhar、J. Moses Babu、A. S. R. Prasad、C. M. Haricharan Raju

  DOI：10.1021/op980093t

  日期：1999.11.1

  In the synthesis and process development of sibutramine (9), the isolation and characterization of two potential by-products namely heptane dinitriles (4a-b) and bis-cyclobutyl alkylamine (10) have been studied, The key steps in the synthesis of sibutramine which have contributed to the formation of above by-products are cycloalkylation of 4-chlorophenyl acetonitrile (1) and tandem Grignard reduction on 1-(4-chlorophenyl) cyclobutyl carbonitrile (3).