9-(dihydroxyamino)-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 9-(dihydroxyamino)-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
• 化学式: C₁₆H₁₃N₃O₃
• 分子量: 295.29
• InChiKey: SQXOQPJROOCRFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  88.6
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Modulation of Neurogenesis with Biguanides and GSK3-beta Agents
  申请人：Barlow Carrolee

  公开号：US20080188457A1

  公开（公告）日：2008-08-07

  The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use of one or more biguanides in combination with one or more GSK3-β agents, to stimulate or activate the formation of new nerve cells.