3-(5-methoxypyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)imidazo[1,2-b]pyridazin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-(5-methoxypyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)imidazo[1,2-b]pyridazin-6-amine
• 英文别名: [3-(5-methoxy-pyridin-3-yl)-imidazo[1,2-b]pyridazin-6-yl]-(tetrahydro-pyran-4-yl)-amine；3-(5-methoxypyridin-3-yl)-N-(oxan-4-yl)imidazo[1,2-b]pyridazin-6-amine
• 化学式: C₁₇H₁₉N₅O₂
• 分子量: 325.37
• InChiKey: KVOCFEBFKVEVIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  73.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE
  申请人：Durand-Reville Thomas

  公开号：US20110021513A1

  公开（公告）日：2011-01-27

  The present invention relates to modulators of IRAK kinase and provides compositions comprising such modulators, as well as methods therewith for treating conditions or diseases mediated by or associated with IRAK kinase.

  本发明涉及IRAK激酶的调节剂，并提供包含这些调节剂的组合物，以及利用这些调节剂治疗由IRAK激酶介导或相关的疾病或病症的方法。
• Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
  申请人：Prien Olaf

  公开号：US20070093490A1

  公开（公告）日：2007-04-26

  The invention relates to novel inhibitors of kinases, methods for preparing such inhibitors, intermediates for the preparation of such inhibitors and uses of such inhibitors.

  这项发明涉及新型激酶抑制剂，制备这种抑制剂的方法，制备这种抑制剂的中间体以及这种抑制剂的用途。
• Inhibitors of MAPK/Erk Kinase
  申请人：Pinkerton B. Anthony

  公开号：US20070049591A1

  公开（公告）日：2007-03-01

  The present invention relates to compounds useful as inhibitors of MEK kinase and methods for the treatment or prevention of cellular proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.

  本发明涉及到作为MEK激酶抑制剂的化合物，以及用于治疗或预防细胞增殖性疾病状态的方法，例如与MEK过度活化有关的疾病，以及由MEK级联调控的疾病。
• IRAK MODULATORS FOR TREATING AN INFLAMMATORY CONDITION, CELL PROLIFERATIVE DISORDER, IMMUNE DISORDER
  申请人：Biogen Idec MA Inc.

  公开号：EP2063962A2

  公开（公告）日：2009-06-03
• US7750000B2
  申请人：——

  公开号：US7750000B2

  公开（公告）日：2010-07-06