<2-Chlor-6-methyl-phenyl>-methyl-sulfon | 4163-82-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: <2-Chlor-6-methyl-phenyl>-methyl-sulfon
• 英文别名: 1-Chloro-3-methyl-2-methylsulfonylbenzene
• CAS: 4163-82-0
• 化学式: C₈H₉ClO₂S
• 分子量: 204.677
• InChiKey: STYIBRMWULGAQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Monothiophosphorsaeure-O,O-dimethylester-S-<2-chlor-6-methyl-phenylester> 生成 <2-Chlor-6-methyl-phenyl>-methyl-sulfon
  参考文献：
  名称：

  水解von O，O-O-二烷基-S-芳基-硫代磷酸酯

  摘要：

  O，O-二烷基-S-芳基-硫代磷酸酯是热不稳定的，并且在约150°的温度下容易分解，形成烷基芳基硫化物和聚合的烷基间-或-聚磷酸盐。在一系列33种硫代磷酸酯中，反应性的差异是根据空间效应和电子效应来合理化的。讨论了热降解的机理，研究了硫醚和苯酚对热分解速率的影响。

  DOI：

  10.1016/s0040-4020(01)98339-5

文献信息

• Substituted Spiro-amide Compounds
  申请人：Schunk Stefan

  公开号：US20100249095A1

  公开（公告）日：2010-09-30

  Substituted spiro-amide compounds corresponding to formula I in which R5 through R8, D, X, Y and Z have defined meanings, processes for preparing such spiro-amide compounds, pharmaceutical compositions containing such compounds, and methods of using such spiro-amide compounds for treating and/or inhibiting disorders or disease states mediated at least in part by the bradykinin 1 receptor.

  将与式I相对应的螺环酰胺化合物替代为R5至R8、D、X、Y和Z具有定义含义的过程，用于制备这种螺环酰胺化合物，含有这种化合物的药物组合物，以及使用这种螺环酰胺化合物治疗和/或抑制至少部分由激肽酶1受体介导的疾病或疾病状态的方法。
• [EN] TYK2 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE TYK2 ET LEURS UTILISATIONS
  申请人：NIMBUS LAKSHMI INC

  公开号：WO2018071794A1

  公开（公告）日：2018-04-19

  The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

  本发明提供了化合物、其组合物以及使用它们来抑制TYK2并治疗TYK2介导的疾病的方法。
• Substituted pyrazoles as p38 kinase inhibitors
  申请人：Naraian S. Ashok

  公开号：US20070078146A1

  公开（公告）日：2007-04-05

  A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R 1 , R 2 , R 3 and R 4 are as described in the specification.

  描述了一类吡唑衍生物，用于治疗p38激酶介导的疾病。特别感兴趣的化合物由公式IA定义，其中R1、R2、R3和R4如规范中所述。
• USE OF SUBSTITUTED SPIROCYCLIC SULFONAMIDOCARBOXYLIC ACIDS, CARBOXYLIC ESTERS THEREOF, CARBOXAMIDES THEREOF AND CARBONITRILES THEREOF OR SALTS THEREOF FOR ENHANCEMENT OF STRESS TOLERANCE IN PLANTS
  申请人：Frackenpohl Jens

  公开号：US20140038822A1

  公开（公告）日：2014-02-06

  Use of substituted spirocyclic sulfonamidocarboxylic acids, -carboxylic esters, -carboxamides and -carbonitriles or salts thereof for enhancement of stress tolerance in plants. The invention relates to the use of spirocyclic sulfonamidocarboxylic acids, -carboxylic esters, -carboxamides and -carbonitriles or salts thereof of the formula (I) in which the respective substituents have the meanings given in the description, for increasing stress tolerance in plants with respect to abiotic stress, and also for increasing plant growth and/or for increasing plant yield.

  使用取代的螺环磺酰胺羧酸、羧酸酯、羧酰胺和羰基腈或其盐来增强植物的耐逆性。本发明涉及使用式（I）中的螺环磺酰胺羧酸、羧酸酯、羧酰胺和羰基腈或其盐，其中各自的取代基在说明中给出，用于增强植物对非生物逆境的耐受性，以及增加植物生长和/或增加植物产量。
• DIFLUOROMETHYLENE COMPOUND
  申请人：SATO PHARMACEUTICAL CO., LTD.

  公开号：US20150191463A1

  公开（公告）日：2015-07-09

  The present invention relates to a compound having an URAT1 inhibitory activity, and to an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, the present invention relates to a compound represented by the formula (I): wherein R 1 is -Q 1 -A 1 or the like; R 2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W 1 , W 2 , W 3 and W 4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR 3 or the like.

  本发明涉及一种具有URAT1抑制活性的化合物，以及一种URAT1抑制剂、降低血尿酸水平的药物和含有该化合物的制剂。更具体地，本发明涉及一种由公式（I）表示的化合物： 其中，R1是-Q1-A1或类似物；R2是氢原子、卤原子、低碳基或类似物；W1、W2、W3和W4各自独立地是氮原子或可选取代基的甲烷基，或类似物；X和Y是单键、氧原子或类似物；Z是羟基、COOR3或类似物。